Methylphenidate Alters Functional Connectivity of Default Mode Network in Drug-Naive Male Adults With ADHD
| Autor: | Bruna Bressan Valentini, Alessandro André Mazzola, Neivo da Silva, Eugenio H. Grevet, Marcelo M. Victor, João Ricardo Sato, Vitor Breda, Rafael G. Karam, Felipe Almeida Picon, Luis Augusto Rohde, Katiane L. Silva, Leonardo Modesti Vedolin, Maurício Anés, Renata B. Cupertino, Claiton H.D. Bau |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Posterior parietal cortex Gyrus Cinguli 03 medical and health sciences 0302 clinical medicine Neurodevelopmental disorder Cortex (anatomy) mental disorders Developmental and Educational Psychology medicine Humans 0501 psychology and cognitive sciences Default mode network Brain Mapping medicine.diagnostic_test Methylphenidate 05 social sciences Brain medicine.disease Magnetic Resonance Imaging Clinical Psychology Drug-naïve medicine.anatomical_structure Attention Deficit Disorder with Hyperactivity Posterior cingulate Functional magnetic resonance imaging Psychology human activities Neuroscience 030217 neurology & neurosurgery 050104 developmental & child psychology medicine.drug |
| Zdroj: | Journal of attention disorders. 24(3) |
| ISSN: | 1557-1246 |
| Popis: | Objective: This study evaluated the hypothesis that methylphenidate immediate release (MPH-IR) treatment would improve Default Mode Network (DMN) within-connectivity. Method: Resting-state functional connectivity of the main nodes of DMN was evaluated in a highly homogeneous sample of 18 drug-naive male adult participants with ADHD. Results: Comparing resting-state functional connectivity functional magnetic resonance imaging (R-fMRI) scans before and after MPH treatment focusing exclusively on within-DMN connectivity, we evidenced the strengthening of functional connectivity between two nodes of the DMN: posterior cingulate cortex (PCC) and left lateral parietal cortex (LLP). Conclusion: Our results contribute to the further understanding on how MPH affects functional connectivity within DMN of male adults with ADHD and corroborate the hypothesis of ADHD being a delayed neurodevelopmental disorder. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|