Reactive Oxygen Species and NOX Enzymes Are Emerging as Key Players in Cutaneous Wound Repair

Autor: Dominik Andre-Levigne, Michael S. Pepper, Brigitte Pittet-Cuénod, Ali Modarressi
Rok vydání: 2017
Předmět:
0301 basic medicine
Pathology
wound healing
Review
medicine.disease_cause
Oxygen
lcsh:Chemistry
wound repair
0302 clinical medicine
NOX enzymes
oxidative stress
re-epithelialization
lcsh:QH301-705.5
Spectroscopy
Skin
reactive oxygen species
chemistry.chemical_classification
NADPH oxidase
biology
General Medicine
Pathophysiology
Computer Science Applications
Cell biology
030220 oncology & carcinogenesis
Oxidation-Reduction
Signal Transduction
medicine.medical_specialty
Neovascularization
Physiologic
chemistry.chemical_element
wound contraction
Catalysis
Inorganic Chemistry
03 medical and health sciences
medicine
Animals
Humans
Physical and Theoretical Chemistry
Blood Coagulation
Molecular Biology
Reactive oxygen species
Organic Chemistry
NADPH Oxidases
hyperbaric oxygen therapy
030104 developmental biology
Enzyme
lcsh:Biology (General)
lcsh:QD1-999
chemistry
Apoptosis
chronic wounds
Chronic Disease
biology.protein
Wound healing
Oxidative stress
Zdroj: International Journal of Molecular Sciences, Vol 18, Iss 10, p 2149 (2017)
International Journal of Molecular Sciences
ISSN: 1422-0067
DOI: 10.3390/ijms18102149
Popis: Our understanding of the role of oxygen in cell physiology has evolved from its long-recognized importance as an essential factor in oxidative metabolism to its recognition as an important player in cell signaling. With regard to the latter, oxygen is needed for the generation of reactive oxygen species (ROS), which regulate a number of different cellular functions including differentiation, proliferation, apoptosis, migration, and contraction. Data specifically concerning the role of ROS-dependent signaling in cutaneous wound repair are very limited, especially regarding wound contraction. In this review we provide an overview of the current literature on the role of molecular and reactive oxygen in the physiology of wound repair as well as in the pathophysiology and therapy of chronic wounds, especially under ischemic and hyperglycemic conditions.
Databáze: OpenAIRE
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