Acute kidney injury in an adult patient with IgA nephropathy and chronic replicative Epstein–Barr virus infection
| Autor: | Hajime Yamazaki, Ami Sato, Takeshi Suzuki, Ichiei Narita, Akira Iguchi, Yumi Ito, Kaito Furuyama, Yuya Sato, Tomoyuki Tanaka, Kazuhiro Yoshita, Naofumi Imai |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Nephrology
Male medicine.medical_specialty Epstein-Barr Virus Infections Herpesvirus 4 Human 030232 urology & nephrology Case Report 030204 cardiovascular system & hematology medicine.disease_cause Asymptomatic Nephropathy 03 medical and health sciences 0302 clinical medicine Internal medicine hemic and lymphatic diseases Medicine Animals Humans Bites and Stings Renal Insufficiency Child Epstein–Barr virus infection Aged Aged 80 and over medicine.diagnostic_test business.industry Acute kidney injury Glomerulonephritis Glomerulonephritis IGA General Medicine Acute Kidney Injury medicine.disease Epstein–Barr virus Culicidae Immunology Chronic Disease DNA Viral Female Renal biopsy medicine.symptom business |
| Popis: | Most of the adult population are infected with Epstein-Barr virus (EBV), but as EBV replication is usually under immune system control, the majority of individuals remain asymptomatic. On the other hand, some individuals continuously retain a high EBV antibody titer and a high EBV DNA load in their blood, suggesting a defect of EBV replication control. To date, only a limited number of reports have addressed the relationship between this chronic form of EBV infection and renal involvement. Here, we describe an 80-year-old woman who developed acute kidney injury shortly after an episode of mosquito bites, accompanied by a severe skin rash, which raised a suspicion of chronic EBV infection. She was subsequently diagnosed as having chronic replicative EBV infection. Renal biopsy revealed a diagnosis of IgA nephropathy with crescent formation. Although the relationship between IgA nephropathy and EBV infection has been discussed, no substantial understanding has yet emerged. The patient's characteristic clinical course suggested that the renal failure may have been partly attributable to chronic EBV infection. This case suggests that physicians may need to consider the possibility that chronic EBV infection may affect the clinical course of IgA nephropathy, or exacerbate the disease. |
| Databáze: | OpenAIRE |
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