Estrogen is essential but not sufficient to induce endometriosis
| Autor: | Mosami Galvankar, Neha Singh, Deepak Modi |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty medicine.drug_class Endometriosis Adipose tissue Choristoma Endometrium General Biochemistry Genetics and Molecular Biology Lesion Mice 03 medical and health sciences Stroma Peritoneum Internal medicine medicine Animals business.industry Estrogens General Medicine medicine.disease Mice Inbred C57BL Transplantation 030104 developmental biology Endocrinology medicine.anatomical_structure Gene Expression Regulation Receptors Estrogen Estrogen Tissue Transplantation Female medicine.symptom General Agricultural and Biological Sciences business |
| Zdroj: | Journal of Biosciences. 42:251-263 |
| ISSN: | 0973-7138 0250-5991 |
| Popis: | Endometriosis is a common gynaecological disorder of unknown aetiology. Among the several factors, estrogen has been implicated as a causative factor in endometriosis. In the present study using mouse model, we assessed the role of estrogen in the initial implantation and growth of endometrium in ectopic locations. Uterine tissues from green fluorescent protein (GFP) mice were transplanted in to the peritoneum of wild type mice in presence and absence of estrogen. As compared to untreated controls, the implantation of uterine tissue at ectopic locations was higher when estrogen was administered to both host and donor animals. However, this effect was not sustained as lesions regressed within 14 days of treatment. Irrespective of the treatment, peritoneal adipose was the most preferred site of lesion establishment. The lesions did not have typical features of the endometriosis (presence of glands and stroma) even after estrogen treatment and the ectopic tissue underwent regression by apoptosis irrespective of treatment. Since estrogen promotes implantation of endometrial tissue to ectopic locations but failure of these ectopic lesions to grow and sustain even in high estrogenic environment we propose that estrogen is necessary but not sufficient to sustain endometriosis. |
| Databáze: | OpenAIRE |
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