Kinetics of bioconcentration and clearance of 28 polychlorinated biphenyl congeners in zebrafish (Brachydanio rerio)
| Autor: | G.P. Zauke, W. Butte, K. Fox |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Stereochemistry
Health Toxicology and Mutagenesis Kinetics Public Health Environmental and Occupational Health Polychlorinated biphenyl Bioconcentration General Medicine Lipid Metabolism Pollution Polychlorinated Biphenyls Partition coefficient chemistry.chemical_compound chemistry Environmental chemistry Lipophilicity Toxicokinetics Animals Uptake rate Clearance rate Zebrafish |
| Zdroj: | Ecotoxicology and environmental safety. 28(1) |
| ISSN: | 0147-6513 |
| Popis: | Bioconcentration experiments were performed on 28 polychlorinated biphenyl (PCB) congeners with NCl = 2 to NCl = 10, evaluating them simultaneously. Bioconcentration factors (BCFs) were calculated from the uptake rate constant (k1) and the clearance rate constant (k2) as BCF = k1/k2. BCFs on a wet weight basis ranged from 7710 to 940,000. They were correlated with octanol-water partition coefficients (P). The curvilinear relationship between log BCF and log P based upon data covering the log P range 5.06 to 8.18. About a log P of 7.38, a range of "optimal lipophilicity," results in highest BCFs for PCBs, above which the degree of bioconcentration decreases. |
| Databáze: | OpenAIRE |
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