Short Term Pre-Operative Oral Corticosteroids—Tissue Remodeling in Chronic Rhinosinusitis with Nasal Polyps
| Autor: | Marek Zdrenka, Paweł K. Burduk, Dariusz Grzanka, Małgorzata Wierzchowska, Paulina Antosik, Paulina Kalińczak-Górna, Kamil Radajewski |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
oral corticosteroids Gastroenterology Article Extracellular matrix 03 medical and health sciences 0302 clinical medicine Fibrosis Prednisone Internal medicine otorhinolaryngologic diseases medicine Eosinophilia Nasal polyps 030223 otorhinolaryngology Total Tissue business.industry chronic rhinosinusitis General Medicine medicine.disease Epithelium Paranasal sinuses medicine.anatomical_structure 030228 respiratory system tissue remodeling Medicine medicine.symptom business medicine.drug |
| Zdroj: | Journal of Clinical Medicine Volume 10 Issue 15 Journal of Clinical Medicine, Vol 10, Iss 3346, p 3346 (2021) |
| ISSN: | 2077-0383 |
| Popis: | Chronic rhinosinusitis is a process involving a number of adverse changes in the mucosa of the paranasal sinuses and nasal polyps. The main histological features of tissue remodeling are changes in epithelial structure, oedema, degradation of ECM (extracellular matrix), angiogenesis, and subepithelial fibrosis. In this study, patients were divided into two groups: group 1—patients with CRSwNP (chronic rhinosinusitis with nasal polyps) taking a nasal steroid and an oral steroid in the preoperative period, and group 2—patients with CRSwNP taking only the nasal steroid in the preoperative period. All samples were subject to histopatologic evaluation. The aim of this study was to investigate the effect of oral corticosteroids and topical steroids on the tissue of paranasal sinuses. We have shown statistically significant decreases in tissue eosinophilia per 5HPF and decreased fibrosis in group 1. No significant differences were presented in the percentage of total tissue oedema, epithelium, neutrophils, basement membrane thickening and vessels. Using systemic administration of 40 mg of prednisone for seven days decreased the counts of eosinophils and decreased fibrosis in the nasal polyps tissue in CRSwNP. |
| Databáze: | OpenAIRE |
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