A review of transfusion practice before, during, and after hematopoietic progenitor cell transplantation
| Autor: | Antoine Sayegh, S. Gerald Sandler, James Gajewski, Thomas R. Klumpp, Viviana V. Johnson |
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| Rok vydání: | 2008 |
| Předmět: |
Blood Platelets
medicine.medical_specialty Blood transfusion Erythrocytes medicine.medical_treatment Immunology MEDLINE Hematopoietic stem cell transplantation Medical Oncology Biochemistry Internal medicine medicine Humans Blood Transfusion Intensive care medicine Review Articles Clinical Trials as Topic Hematology business.industry Hematopoietic Stem Cell Transplantation Immunosuppression Transfusion medicine Cell Biology Hematopoietic Stem Cells Surgery Transplantation Hematopoietic progenitor surgical procedures operative Gamma Rays Immune System Cytomegalovirus Infections Blood Component Removal Splenectomy business |
| Zdroj: | Blood. 112(8) |
| ISSN: | 1528-0020 |
| Popis: | The increased use of hematopoietic progenitor cell (HPC) transplantation has implications and consequences for transfusion services: not only in hospitals where HPC transplantations are performed, but also in hospitals that do not perform HPC transplantations but manage patients before or after transplantation. Candidates for HPC transplantation have specific and specialized transfusion requirements before, during, and after transplantation that are necessary to avert the adverse consequences of alloimmunization to human leukocyte antigens, immunohematologic consequences of ABO-mismatched transplantations, or immunosuppression. Decisions concerning blood transfusions during any of these times may compromise the outcome of an otherwise successful transplantation. Years after an HPC transplantation, and even during clinical remission, recipients may continue to be immunosuppressed and may have critically important, special transfusion requirements. Without a thorough understanding of these special requirements, provision of compatible blood components may be delayed and often urgent transfusion needs prohibit appropriate consultation with the patient's transplantation specialist. To optimize the relevance of issues and communication between clinical hematologists, transplantation physicians, and transfusion medicine physicians, the data and opinions presented in this review are organized by sequence of patient presentation, namely, before, during, and after transplantation. |
| Databáze: | OpenAIRE |
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