A case-control association of RANTES (-28C G) and CCR5-Delta32 polymorphisms with Parkinson's disease in Indians
| Autor: | Solomon F. D. Paul, Teena Koshy, Vettriselvi Venkatesan, Narayani Subramanian, Srishti Ramanathan |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult Male Chemokine medicine.medical_specialty Genotype Receptors CCR5 India Single-nucleotide polymorphism Pilot Projects Polymorphism Single Nucleotide Pathogenesis 03 medical and health sciences Chemokine receptor 0302 clinical medicine Asian People Polymorphism (computer science) Internal medicine medicine Humans Genetic Predisposition to Disease Allele Chemokine CCL5 Aged Aged 80 and over biology General Neuroscience Parkinson Disease Middle Aged Genotype frequency 030104 developmental biology Endocrinology Case-Control Studies biology.protein Female 030217 neurology & neurosurgery |
| Zdroj: | Neuroscience letters. 739 |
| ISSN: | 1872-7972 |
| Popis: | Recent studies have suggested that chemokines and their receptors are involved in several neurodegenerative disorders. Also, numerous lines of evidence have indicated that inflammatory processes are involved in the pathogenesis of Parkinson’s disease (PD). We have examined whether single nucleotide polymorphisms at the genes encoding chemokines RANTES (-28 C > G), RANTES (-403 A > G) MCP-1 (-2518 A > G), and chemokine receptors CCR2 (+190 G > A) and CCR5 (-Δ32) were associated with sporadic PD risk in the Indian population. This pilot case-control association study included 97 PD patients and 100 control subjects, who were all genotyped with PCR-RFLP for the five polymorphisms. There was no statistically significant difference in the genotype frequencies between the cases and controls for the MCP1 (-2518 A > G), RANTES (-403 A > G) and CCR2 (+190 G > A) polymorphisms. However, the results revealed a significant difference in the frequency of the heterozygous CG genotype for the RANTES (-28 C > G) polymorphism (OR = 0.49, p = 0.03) between the cases and controls. A negative association was demonstrated in the dominant model where, compared with the GG genotype, a higher frequency of the GC + CC genotype was observed in the controls. Also, a statistically significant higher frequency of the CCR5 heterozygous genotype WT/Δ32 in the controls was observed (OR = 0.31, p = 0.04). Combined genotype analysis revealed that the allele combination of G-A-G-C of CCR2 (+190G > A), MCP-1 (-2518 A/G), RANTES (-403 A/G) and RANTES (-28 C/G) respectively had a risk association with PD (OR = 6.18, p = 0.005). |
| Databáze: | OpenAIRE |
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