| Autor: |
Jonas Lehmacher, Johannes T Neumann, Nils Arne Sörensen, Alina Goßling, Samuel Emil Schmidt, Tanja Zeller, Stefan Blankenberg, Dirk Westermann, Peter M Clemmensen |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Lehmacher, J, Neumann, J T, Sörensen, N A, Goßling, A, Schmidt, S E, Zeller, T, Blankenberg, S, Westermann, D & Clemmensen, P M 2023, ' Diagnostic performance of a device for acoustic heart sound analysis in patients with suspected myocardial infarction ', Open Heart, vol. 10, no. 1, e002090 . https://doi.org/10.1136/openhrt-2022-002090 |
| DOI: |
10.1136/openhrt-2022-002090 |
| Popis: |
Background As only a small proportion of patients with chest pain suffers from myocardial infarction (MI), safe rule-out of MI is of immense importance. Recently an ultrasensitive microphone performing diastolic heart sound analysis (CADScorSystem) for rule-out of coronary artery disease (CAD) has emerged. In this explorational study, we aimed to evaluate the feasibility of the CADScorSystem for diagnosis of MI in the setting of a large emergency department.Methods Patients presenting to the emergency department with suspected MI were included. Acoustic heart sound analysis was performed in all patients and automated CAD-score values were calculated via a device-embedded algorithm, which also requires inclusion of three clinical variables: age, sex and presence of hypertension. Patients additionally received serial high-sensitive troponin T measurement measurements to assess the final diagnosis according to third Universal Definition of Myocardial Infarction applying the European Society of Cardiology 0 hour/3 hours algorithm. Diagnostic parameters for MI, considering different CAD-score cut-offs, were computed.Results Of 167 patients, CAD-scores were available in 61.1off value of lt;20, CAD-score had a negative predictive value (NPV) of 90.7 (78.4textendash96.3). The corresponding positive predictive value (PPV) was 6.8 (2.7textendash16.2). For the adjusted CAD-score (age, sex, hypertension), at a cut-off value of lt;20, NPV was 90.0 (59.6textendash99.5) with a PPV of 10.8 (5.3textendash20.6).Conclusion In this explorative analysis, a transcutaneous ultrasensitive microphone for heart sound analysis resulted in a high NPV analogous to the findings in rule-out of stable CAD in elective patients yet inferior to serial high-sensitivity cardiac troponin measurements and does not seem feasible for application in an emergency setting for rule-out of MI.Trial registration number NCT02355457.All data relevant to the study are included in the article or uploaded as online supplemental information. Background As only a small proportion of patients with chest pain suffers from myocardial infarction (MI), safe rule-out of MI is of immense importance. Recently an ultrasensitive microphone performing diastolic heart sound analysis (CADScorSystem) for rule-out of coronary artery disease (CAD) has emerged. In this explorational study, we aimed to evaluate the feasibility of the CADScorSystem for diagnosis of MI in the setting of a large emergency department. Methods Patients presenting to the emergency department with suspected MI were included. Acoustic heart sound analysis was performed in all patients and automated CAD-score values were calculated via a device-embedded algorithm, which also requires inclusion of three clinical variables: age, sex and presence of hypertension. Patients additionally received serial high-sensitive troponin T measurement measurements to assess the final diagnosis according to third Universal Definition of Myocardial Infarction applying the European Society of Cardiology 0 hour/3 hours algorithm. Diagnostic parameters for MI, considering different CAD-score cut-offs, were computed. Results Of 167 patients, CAD-scores were available in 61.1%. A total of eight patients were diagnosed with MI. At a cut-off value of |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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