Relationship between CT features and high preoperative serum carcinoembryonic antigen levels in early-stage lung adenocarcinoma
| Autor: | Norihiko Yoshimura, Motohiko Yamazaki, Akiko Tasaki, Yohei Ikeda, Ryosuke kunii, Suguru Sato, Hiroyuki Ishikawa, Hidefumi Aoyama |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Lung Neoplasms Adenocarcinoma of Lung Adenocarcinoma Gastroenterology Preoperative care Carcinoembryonic antigen Internal medicine Preoperative Care Humans Medicine Radiology Nuclear Medicine and imaging Stage (cooking) Pathological Aged Retrospective Studies Aged 80 and over Univariate analysis Lung biology business.industry Retrospective cohort study General Medicine Middle Aged Prognosis medicine.disease digestive system diseases Carcinoembryonic Antigen medicine.anatomical_structure Multivariate Analysis biology.protein Female Tomography X-Ray Computed business |
| Zdroj: | Clinical Radiology. 69:559-566 |
| ISSN: | 0009-9260 |
| Popis: | To assess the relationship between thin-section computed tomography (CT) features of primary tumour and high preoperative serum carcinoembryonic antigen (CEA) levels that reportedly suggest poor prognoses in early-stage lung adenocarcinoma.Two hundred and seventy-five consecutive patients who underwent resection of pathological stage I (T1-2aN0M0) adenocarcinomas with a maximum diameter of ≤ 3 cm (144 men, 131 women; mean age 67.8 years) were enrolled. CT features of the primary tumours and clinical characteristics of these patients were statistically evaluated to identify the factors associated with high serum CEA levels (5 ng/ml).Eighty-one patients (29.5%) had high serum CEA levels. In univariate analysis, lower ground-glass opacity ratio (p0.001), lower tumour shadow disappearance rate (TDR: the ratio of tumour area in mediastinal window to that of lung window, p0.001), presence of notch (p = 0.015), and coexistence with bullae or honeycomb cysts (p0.001) were observed more frequently in the group with high serum CEA levels than that of the group with normal levels. TDR [odds ratio (OR) 0.984; 95% confidence interval (CI): 0.976-0.993; p0.001] and coexistence with bullae or honeycomb cysts (OR = 3.08; 95% CI: 1.55-6.12; p = 0.001) remained significant, even after adjusting patients' age, gender, and smoking status.Adenocarcinomas with lower TDR and coexisting with bullae or honeycomb cysts are associated with high preoperative serum CEA levels. Although some CEA elevations may be due to benign pulmonary diseases, such tumours are suspected to have poor prognoses, even for early-stage diseases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect