Successful management of acute thromboembolic disease complicated with heparin induced thrombocytopenia type II (HIT II): a case series
| Autor: | Maria Antoniadou, Pandora Christaki, Angelos Megalopoulos, Eva Serasli, George Trellopoulos, Georgia Papaioannou, Venetia Tsara, Vassilis Kalpakidis |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
business.industry medicine.drug_class lcsh:RC633-647.5 Anticoagulant Inferior vena cava filter Case Report Hematology Heparin lcsh:Diseases of the blood and blood-forming organs medicine.disease Fondaparinux Thrombosis Pulmonary embolism Surgery Heparin-induced thrombocytopenia medicine Anticoagulant Agent business medicine.drug |
| Zdroj: | Thrombosis Journal, Vol 6, Iss 1, p 9 (2008) Thrombosis Journal |
| ISSN: | 1477-9560 |
| Popis: | Heparin-induced thrombocytopenia type II (HIT II) is a rare immune-mediated complication of heparin. The diagnosis of HIT is considered in patients exposed to heparin, presenting with thrombocytopenia and thrombosis. We present two cases with massive pulmonary embolism and HIT, successfully treated with the administration of fondaparinux, an alternative anticoagulant, combined with the insertion of an inferior vena cava filter for the prevention of new thromboembolic events. The two cases supplement the available data of the use of fondaparinux in patients with HIT and pulmonary embolism, before further large studies establish its efficacy and safety in this group of patients. Moreover, the management of these patients reveals the need for future evaluation of the combined therapy of alternative anticoagulant agents with the placement of vena cava filters. |
| Databáze: | OpenAIRE |
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