Association of KRAS mutation with tumor deposit status and overall survival of colorectal cancer
| Autor: | Wenwei Hu, Lanjing Zhang, Yong Lin, Zhaohui Feng, Meifang Zhang, Nan Gao, Jing-Ping Yun, Kun Hu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
Oncology Cancer Research medicine.medical_specialty Colorectal cancer Logistic regression medicine.disease_cause Article Cohort Studies Proto-Oncogene Proteins p21(ras) 03 medical and health sciences 0302 clinical medicine Internal medicine Overall survival medicine Humans 030212 general & internal medicine neoplasms Survival rate Aged Proportional Hazards Models Retrospective Studies 030304 developmental biology 0303 health sciences business.industry Proportional hazards model Hazard ratio Cancer Microsatellite instability Retrospective cohort study Middle Aged Prognosis medicine.disease United States digestive system diseases 3. Good health Logistic Models 030220 oncology & carcinogenesis Mutation Female Microsatellite Instability KRAS Colorectal Neoplasms business Kras mutation |
| Zdroj: | Cancer Causes Control |
| ISSN: | 1573-7225 0957-5243 |
| Popis: | BackgroundThe recent staging manual upstages Node-negative tumor-deposit positive colorectal cancer (CRC) from N0 to N1c category, while the development of tumor-deposit presence is poorly understood. Meanwhile, Kras mutation is associated with progression of CRC, but its link to tumor-deposit status is unclear.MethodThis retrospective cohort study included the patients with incidental CRC diagnosed during 2010-2014 in the National Cancer Database and recorded statuses of Kras and tumor deposit. We conducted multivariable logistic regression and Cox regression analyses to investigate the factors associated with tumor-deposit status and overall-survival, respectively.ResultsA total of 48,200 CRC patients with Kras status were included in the study (25,407 [52.7%] men, 25,648[46.8%] ConclusionKras mutation is independently associated with tumor-deposit presence, and a worse overall survival of CRC with or without tumor-deposit. Therefore, it may play a role in the development of tumor deposits and serve as a target for CRC treatment. |
| Databáze: | OpenAIRE |
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