The role of ERCC1 and AFP gene polymorphism in hepatocellular carcinoma
| Autor: | Ling-Sha Huang, Bo Zhu, Yu-Liang Huang, Jian Ye, Zhi-Min Liu, Hui-Liu Zhao, Min Fang, Jun-Rong Wu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Linkage disequilibrium medicine.medical_specialty Carcinoma Hepatocellular Observational Study Locus (genetics) Single-nucleotide polymorphism Gastroenterology Polymorphism Single Nucleotide 03 medical and health sciences alpha-fetoprotein 0302 clinical medicine Internal medicine Genotype medicine Biomarkers Tumor Humans Genetic Predisposition to Disease 030212 general & internal medicine Allele neoplasms Alleles excision repair cross-complementation group 1 Chi-Square Distribution business.industry Haplotype Liver Neoplasms General Medicine hepatocellular carcinoma single-nucleotide polymorphism Middle Aged medicine.disease Endonucleases digestive system diseases DNA-Binding Proteins Logistic Models 030220 oncology & carcinogenesis Hepatocellular carcinoma Case-Control Studies Female Gene polymorphism alpha-Fetoproteins business Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 0025-7974 |
| Popis: | The aim of this study was to evaluate the effects of polymorphisms in excision repair cross-complementation group 1 (ERCC1) and alpha-fetoprotein (AFP) genes and their haplotypes on the susceptibility to hepatocellular carcinoma (HCC), and to decipher the association between single-nucleotide polymorphisms (SNPs) and clinicopathologic characteristics of HCC. Peripheral blood DNA was extracted from 206 subjects. SNaPshot technique was used for genotyping 5 SNP sites of the ERCC1 rs735482, rs1046282, rs3212948, and AFP rs737241, rs4024 genotypes. Chi-squared test and logistic regression model were used to analyze the relationship of different genotypes or haplotype and the susceptibility and clinicopathologic characteristics of HCC. The frequency of GG.GA and AA genotypes at the AFP rs737241 site in the case and control groups showed statistically significant differences (P |
| Databáze: | OpenAIRE |
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