Exercise as Gene Therapy: BDNF and DNA Damage Repair
| Autor: | Robin H Schmidt, Jeffrey H Boatright, John M. Nickerson |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
DNA Repair DNA repair DNA damage Genetic enhancement Disease Bioinformatics medicine.disease_cause Article 03 medical and health sciences Neurotrophic factors medicine Animals Humans Exercise Brain-derived neurotrophic factor Gene Editing business.industry Brain-Derived Neurotrophic Factor Neurodegeneration Clinical Studies as Topic Neurodegenerative Diseases General Medicine medicine.disease body regions Ophthalmology Oxidative Stress 030104 developmental biology business Oxidative stress DNA Damage |
| Zdroj: | Asia-Pacific journal of ophthalmology (Philadelphia, Pa.). 5(4) |
| ISSN: | 2162-0989 |
| Popis: | DNA damage is a common feature of neurodegenerative illnesses, and the ability to repair DNA strand breaks and lesions is crucial for neuronal survival, reported by Jeppesen et al (Prog Neurobiol. 2011;94:166-200) and Shiwaku et al (Curr Mol Med. 2015;15:119-128). Interventions aimed at repairing these lesions, therefore, could be useful for preventing or delaying the progression of disease. One potential strategy for promoting DNA damage repair (DDR) is exercise. Although the role of exercise in DDR is not understood, there is increasing evidence that simple physical activity may impact clinical outcomes for neurodegeneration. Here, we discuss what is currently known about the molecular mechanisms of brain-derived neurotrophic factor and how these mechanisms might influence the DDR process. |
| Databáze: | OpenAIRE |
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