Impact of environmental chemicals on craniofacial skeletal development: Insights from investigations using zebrafish embryos
| Autor: | Tianjie Wu, Wenlong Huang, Kusheng Wu, William W. Au |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Embryo
Nonmammalian animal structures 010504 meteorology & atmospheric sciences Skeletal anomalies Health Toxicology and Mutagenesis Morphogenesis Developmental toxicity Danio 010501 environmental sciences Biology Toxicology Bioinformatics 01 natural sciences Skeletal malformation Animals Humans Pesticides Craniofacial Zebrafish 0105 earth and related environmental sciences General Medicine biology.organism_classification Pollution Teratogens Zebrafish embryo Water Pollutants Chemical |
| Zdroj: | Environmental Pollution. 286:117541 |
| ISSN: | 0269-7491 |
| DOI: | 10.1016/j.envpol.2021.117541 |
| Popis: | Craniofacial skeletal anomalies are among the most common structural birth defects around the world. Various studies using human populations and experimental animals have shown that genetic and environmental factors play significant roles in the causation and progression of these anomalies. Environmental factors, such as teratogens and toxin mixtures, induce craniofacial anomalies are gaining heightened attention. Among experimental investigations, the use of the zebrafish (Danio rerio) has been increasing. A major reason for the increased use is that the zebrafish boast a simple craniofacial structure, and facial morphogenesis is readily observed due to external fertilization and transparent embryo, making it a valuable platform to screen and identify environmental factors involved in the etiology of craniofacial skeletal malformation. This review provides an update on harmful effects from exposure to environmental chemicals, involving metallic elements, nanoparticles, persistent organic pollutants, pesticides and pharmaceutical formulations on craniofacial skeletal development in zebrafish embryos. The collected data provide a better understanding for induction of craniofacial skeletal anomalies and for development of better prevention strategies. |
| Databáze: | OpenAIRE |
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