Effects of Cyclooxygenases Inhibitors on Vasoactive Prostanoids and Thrombin Generation at the Site of Microvascular Injury in Healthy Men
| Autor: | Filip Mejza, Andrzej Szczeklik, Adam Cmiel, Ewa Tuleja |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Blood Platelets Male Naproxen Bleeding Time Diclofenac Thromboxane Prostacyclin 6-Ketoprostaglandin F1 alpha Pharmacology prostaglandins Lactones Double-Blind Method Fibrinolytic Agents Antithrombotic medicine risk factors Humans Cyclooxygenase Inhibitors Sulfones Rofecoxib cyclooxygenase inhibitors Aspirin Cyclooxygenase 2 Inhibitors business.industry Anti-Inflammatory Agents Non-Steroidal Thrombin Membrane Proteins medicine.disease thrombin Isoenzymes Thromboxane B2 myocardial infarction Cyclooxygenase 2 Prostaglandin-Endoperoxide Synthases Anesthesia Rheumatoid arthritis Cyclooxygenase 1 Endothelium Vascular Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Arteriosclerosis, Thrombosis, and Vascular Biology. 23:1111-1115 |
| ISSN: | 1524-4636 1079-5642 |
| Popis: | Objective—Balance between vasoactive prostanoids that contribute to homeostasis of the circulatory system can be affected by cyclooxygenases inhibitors. Results of a recent large clinical trial show that myocardial infarction was more frequent among patients with rheumatoid arthritis treated with the selective cyclooxygenase-2 inhibitor rofecoxib compared with those treated with naproxen. Whether this difference was attributable to deleterious cardiovascular effects of rofecoxib or cardioprotective effects of naproxen has not been determined. We tested the hypothesis that naproxen, contrary to rofecoxib, exerts antithrombotic effects.Methods and Results—Forty-five healthy men were randomized to receive a 7-day treatment with rofecoxib (50 mg/d), naproxen (1000 mg/d), aspirin (75 mg/d), or diclofenac (150 mg/d). Formation of thromboxane, prostacyclin, and thrombin in the bleeding-time blood at the site of standardized microvascular injury was assessed before and after treatment. Naproxen, like aspirin, caused significant reduction of both thromboxane and prostacyclin, whereas diclofenac depressed prostacyclin synthesis but had no effect on tromboxane formation. Naproxen and aspirin significantly suppressed thrombin generation. Diclofenac showed a similar tendency, which did not reach statistical significance. Rofecoxib had no effect on any variables measured.Conclusions—In healthy men, naproxen exerts an antithrombotic effect at least as potent as aspirin, whereas rofecoxib does not affect hemostatic balance. |
| Databáze: | OpenAIRE |
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