Revealing highly conserved regions in the E6 protein among distinct human papillomavirus types using comparative analysis of multiple sequence alignments
| Autor: | Jane Eyre Gabriel, R P de Farias, D D L G de Figueiredo |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
E6 protein
Biology Genome lcsh:Botany Genotype lcsh:Zoology medicine Humans lcsh:QL1-991 lcsh:Science lcsh:QH301-705.5 Conserved Sequence Sequence (medicine) Human papillomavirus types Genetics Protein coding Cervical cancer Human papillomavirus 16 Base Sequence Human papillomavirus 18 Head and neck tumors Oncogene Proteins Viral medicine.disease lcsh:QK1-989 DNA-Binding Proteins Repressor Proteins lcsh:Biology (General) lcsh:Q General Agricultural and Biological Sciences Sequence Alignment |
| Zdroj: | Brazilian Journal of Biology, Vol 73, Iss 2, Pp 449-450 |
| ISSN: | 1678-4375 |
| Popis: | Several epidemiological and molecular studies have confirmed that cervical infection by certain human papillomaviruses (HPV) types is a precursor of the genesis of cervical neoplasia (Gravitt, 2011; Guzman-Olea et al., 2012). It is yet well elucidated that high risk genotypes lead to the development of cervical cancer and are also associated with other mucosal anogenital, head and neck tumors. The HPV genome is approximately 8 kb in length and is divided into three regions, the non-coding long control region (LCR, ~1 kb), and the protein coding early (E, ~4 kb) and late (L, ~3 kb) regions (Ganguly and Parihar, 2009). The viral genome encodes six early (E1, E2, E4, E5, E6 and E7) and two late (L1 and L2) proteins. HPV |
| Databáze: | OpenAIRE |
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