Implications of PEGylation of Carbon Nanotubes for Central Nervous System Bioavailability
| Autor: | Livia S. Gomides, Daniela M. Barros, Carolina S. Peixoto, Adelina P. Santos, Marcos F. Cordeiro, Lidiane Dal Bosco, Arthur P. Cordeiro, Gisele Eva Bruch |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Biodistribution
Central nervous system 02 engineering and technology Blood–brain barrier Polyethylene Glycols 03 medical and health sciences 0302 clinical medicine Central Nervous System Diseases medicine Animals Humans Nanotechnology Tissue Distribution Pharmacology Nanotubes Carbon business.industry General Neuroscience 021001 nanoscience & nanotechnology Biocompatible material Bioavailability medicine.anatomical_structure Blood-Brain Barrier Drug delivery PEGylation 0210 nano-technology business Neuroscience 030217 neurology & neurosurgery Clearance |
| Zdroj: | CNS & Neurological Disorders - Drug Targets. 16 |
| ISSN: | 1871-5273 |
| DOI: | 10.2174/1871527316666170731111735 |
| Popis: | BACKGROUND AND OBJECTIVE In this mini-review, we have compiled the most recent and comparable information to shed light on the action of PEGylation in the biodistribution of carbon nanotubes (CNT) in the central nervous system (CNS). It is well known that due to the complexity of the CNS and the severity of the outcome following changes in this system, this is one of the areas where there are more investments in research to develop new technologies and approaches for more effective and less invasive treatments. The CNS is highly protected against toxic and invasive microorganisms thanks to the blood brain barrier (BBB), but this protection also prevents the passage of potentially beneficial molecules for the treatment of neurological disorders. Nanotechnology attempts to develop nanocompounds that are biocompatible and non-immunogenic, and that are able to cross the BBB in therapeutic amounts without causing damage and to diffuse through nerve tissue. These compounds should also be cleared and biodistributed properly, being capable of performing drug delivery exclusively for CNS pathologies, such as neurodegenerative diseases (Parkinson's and Alzheimer's) and brain tumors. CONCLUSION In this way, this review focuses on CNT PEGylation, aiming to help in the development of viable and effective nanomedicines for neuroscience applications. |
| Databáze: | OpenAIRE |
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