Bronchoalveolar Lavage in Hypersensitivity Pneumonitis: A Series of 139 Patients
| Autor: | Caillaud, Denis M, Vergnon, Jean M, Madroszyk, Anne, Melloni, Boris M, Murris, Marlene, Dalphin, Jean-Charles, Renseigné, Non |
|---|---|
| Přispěvatelé: | Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Laboratoire Chrono-environnement ( LCE ), Université Bourgogne Franche-Comté ( UBFC ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Franche-Comté ( UFC ) |
| Rok vydání: | 2012 |
| Předmět: |
Male
Pathology Lymphocyte MESH : Aged Bronchoalveolar Lavage [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract MESH : Farmer's Lung MESH: Aged 80 and over Immunology and Allergy Eosinophilia MESH : Female Aged 80 and over MESH: Aged MESH : Bronchoalveolar Lavage Fluid MESH: Middle Aged MESH: Bronchoalveolar Lavage medicine.diagnostic_test General Medicine Middle Aged MESH : Adult respiratory system medicine.anatomical_structure MESH: Young Adult Female medicine.symptom Bronchoalveolar Lavage Fluid MESH : Bronchoalveolar Lavage Hypersensitivity pneumonitis Alveolitis Extrinsic Allergic Adult medicine.medical_specialty Adolescent MESH : Male MESH : Alveolitis Extrinsic Allergic Immunology CD4-CD8 Ratio MESH : Young Adult MESH: Alveolitis Extrinsic Allergic Young Adult Antigen MESH : Adolescent medicine Humans MESH : Middle Aged MESH : Aged 80 and over Aged MESH: Adolescent MESH: Farmer's Lung Pharmacology MESH: Humans Lung MESH: Bronchoalveolar Lavage Fluid business.industry MESH : Humans MESH: Adult medicine.disease MESH: Male Neutrophilia respiratory tract diseases Bronchoalveolar lavage MESH : CD4-CD8 Ratio Farmer's Lung MESH: CD4-CD8 Ratio business MESH: Female [ SDV.MHEP.PSR ] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract CD8 |
| Zdroj: | Inflammation and Allergy-Drug Targets Inflammation and Allergy-Drug Targets, Bentham Science Publishers, 2012, 11 (1), pp.15-9 |
| ISSN: | 1871-5281 |
| DOI: | 10.2174/187152812798889330 |
| Popis: | International audience; Hypersensitivity pneumonitis (HP) is characterized by a lymphocytic alveolitis, classically delineated by an increase of CD8+ lymphocytes, with an inversion of the CD4+/CD8+ ratio. The aim of this study is both to describe the yield and cell bronchoalveolar lavage (BAL) profile and to revisit the assumption of low BAL CD4/CD8 ratio in the diagnosis of HP. A multicentric study was conducted on 139 patients who fulfilled the standardized diagnostic criteria of HP, mainly affected by farmer's lung. Mean total cell count in BAL fluid was 594 ± 401.10(3) cells /ml. Prominent absolute lymphocytic alveolitis, moderate neutrophilia, and mild eosinophilia and mastocytosis were found. Mean CD4/CD8 ratio was 3.8 ± 6.1 (median 2.1). Thirty four percent of the patients showed lymphocytic CD8 alveolitis (ratio < 1). The CD4/CD8 ratio was not different between forms, etiologies of HP, and time elapsed since last antigen exposure, but was higher in women (p=0.02). BAL in HP shows high total cell and lymphocyte counts, moderate neutrophilia, and mild eosinophilia and mastocytosis. An absence of low CD4/CD8 ratio should not at all exclude diagnosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|