Do small lapses predict relapse to smoking behavior under bupropion treatment?
| Autor: | Paul Wileyto, Freda Patterson, Raymond Niaura, Leonard Epstein, Richard Brown, Janet Audrain-McGovern, Larry Hawk, Caryn Lerman |
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| Rok vydání: | 2004 |
| Předmět: |
Oncology
Adult Counseling Male medicine.medical_specialty Subsequent Relapse medicine.medical_treatment Context (language use) law.invention Placebos Randomized controlled trial Dopamine Uptake Inhibitors law Recurrence Internal medicine Medicine Humans Bupropion Cognitive Behavioral Therapy business.industry Proportional hazards model Hazard ratio Public Health Environmental and Occupational Health Tobacco Use Disorder Clinical trial Treatment Outcome Anesthesia Smoking cessation Female Smoking Cessation business medicine.drug |
| Zdroj: | Nicotinetobacco research : official journal of the Society for Research on Nicotine and Tobacco. 6(2) |
| ISSN: | 1462-2203 |
| Popis: | Although bupropion is known to be an effective aid to smoking cessation, little is known about its mode of action. In the present study we tested the hypothesis that bupropion reduces the likelihood that a smoking lapse, or slip, leads to a subsequent relapse. This hypothesis was tested in the context of a clinical trial of bupropion as a smoking cessation aid, using Cox regression and representing lapse history as a discrete time-varying covariate. Bupropion treatment reduced the probability of relapse during the treatment phase (hazard ratio, or HR=.421, p< or =.000) but not during the follow-up phase (end of treatment to 6 months, HR=.896, p< or=.67). As anticipated, having small lapses during treatment contributed to or predicted subsequent relapse, both during treatment (HR=2.897, p< or =.000) and during follow-up (HR=2.320, p< or=.008). Although an interaction was found between drug treatment and lapse history in predicting subsequent failure during the treatment phase, the finding suggested that drug slightly increased the effect of lapse on eventual failure during treatment (HR=1.706, p |
| Databáze: | OpenAIRE |
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