Effect of dexmedetomidine priming on convulsion reaction induced by lidocaine
| Autor: | Xiao-Ling Luo, Yanping Zhan, Jian Huang, Xi-Feng Wang, Weicheng Liu, Ben-Chao Hou, Shi-Biao Chen |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Lidocaine Administration Topical Priming (immunology) Observational Study Pharmacology Inhibitory postsynaptic potential 03 medical and health sciences 0302 clinical medicine 030202 anesthesiology Seizures Convulsion medicine Adrenergic alpha-2 Receptor Agonists Animals Dexmedetomidine Anesthetics Local chemistry.chemical_classification Dose-Response Relationship Drug business.industry Glutamate receptor dexmedetomidine inhibitory amino acids General Medicine Amino acid Disease Models Animal chemistry convulsion excitatory amino acids 030220 oncology & carcinogenesis Anesthesia Glycine Rabbits medicine.symptom business medicine.drug Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 |
| Popis: | To study the effect of dexmedetomidine priming on convulsion reaction induced by lidocaine. The New Zealand white rabbits were applied for the mechanism study of dexmedetomidine priming for preventing convulsion reaction induced by lidocaine. The influence of dexmedetomidine priming with different doses on the time for convulsion occurrence and the duration time of convulsion induced by lidocaine, as well as contents of excitatory amino acids (aspartate [Asp], glutamate [Glu]) and inhibitory amino acids (glycine [Gly], γ-aminobutyric acid [GABA]) in the brain tissue were investigated. With 3 and 5 μg/kg dexmedetomidine priming, the occurrence times of convulsion were prolonged from 196 seconds to 349 and 414 seconds, respectively. With dexmedetomidine priming, the contents of excitatory amino acids (Asp, Glu) were much reduced at occurrence time of convulsion comparing with that without dexmedetomidine priming, while content of inhibitory amino acids Gly was much enhanced. The application of dexmedetomidine before local anesthetics can improve intoxication dose threshold of the lidocaine, delay occurrence of the convulsion, and helped for the recovery of convulsion induced by lidocaine. The positive effect of dexmedetomidine on preventing convulsion would owe to not only the inhibition of excitatory amino acids (Asp, Glu), but also the promotion of inhibitory amino acids Gly secretion. |
| Databáze: | OpenAIRE |
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