Advanced Formulation Design for Topical Creams Assisted with Vibrational Spectroscopic Imaging
| Autor: | Yosuke Ozawa, Toshiro Fukami, Tatsuo Koide, Yutaro Watanabe, Daisuke Ando |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Glycerol
Administration Topical Drug Compounding Skin Cream Analytical chemistry Cosmetics Spectrum Analysis Raman Dosage form symbols.namesake chemistry.chemical_compound Drug Discovery Microscopy Humans Isopropyl myristate Active ingredient Microscopy Confocal Myristates General Chemistry General Medicine Solubility chemistry Benzyl alcohol Attenuated total reflection Solvents symbols Absorption (chemistry) Raman spectroscopy |
| Zdroj: | Chemical and Pharmaceutical Bulletin. 69:271-277 |
| ISSN: | 1347-5223 0009-2363 |
| Popis: | Vibrational spectroscopic imaging has become useful analytical tools for quality control of drug products. In this study, we applied microscopic attenuated total reflection (ATR)-IR and confocal Raman microscopy to elucidate microscopic structure of creams and for the formulation design in the development of semi-solid drug products. The model creams were prepared with prednisolone (PRD) and fluconazole (FLC) as active pharmaceutical ingredients and oily solvents such as mineral oil (MO), isopropyl myristate (IPM), benzyl alcohol (BA) and diethyl sebacate (DES). As a result of microscopic ATR-IR imaging, several domains indicating oily internal phase were observed, which had absorption around 1732 and 1734 cm-1 derived from MO, IPM and DES. In addition, domains of BA around 1009 cm-1 were observed at the complemental or similar position in the formulation with MO or DES, respectively. These results suggested that the creams were oil-in-water type and the distribution of domains would reflect the compatibility of the solvents. The contents of PRD and BA were determined quantitatively in each layer after the intentional separation of the creams and the results agreed well with the imaging analysis. Whereas, confocal Raman imaging allowed to visualize the distribution of the components in depth direction as well as two-dimensional plane. In particular, the Raman imaging would ensure the coexistence of FLC and BA as oily phase in the cream. From these results, the feasibility of spectroscopic imaging techniques was successfully demonstrated for the formulation design of semi-solid dosage forms. |
| Databáze: | OpenAIRE |
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