Comprehensive Genome-Wide Approaches to Activity-Dependent Translational Control in Neurons

Autor: Jun Cho, Han Kyoung Choe
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Review
Genome
lcsh:Chemistry
local translation
Translational regulation
Transcriptional regulation
activity-dependent gene expression
Ribosome profiling
lcsh:QH301-705.5
Spectroscopy
Neurons
Regulation of gene expression
Neuronal Plasticity
TOR Serine-Threonine Kinases
Brain
High-Throughput Nucleotide Sequencing
translational control
General Medicine
phosphotrap
Computer Science Applications
Ribonucleoproteins
Autism spectrum disorder
depression
Signal Transduction
autism spectrum disorder
Biology
Catalysis
Inorganic Chemistry
Memory
medicine
Animals
Humans
Learning
Physical and Theoretical Chemistry
Molecular Biology
Gene
ribosome profiling
Organic Chemistry
medicine.disease
Gene Expression Regulation
ribotag
lcsh:Biology (General)
lcsh:QD1-999
Polyribosomes
Synaptic plasticity
Protein Processing
Post-Translational
Ribosomes
Neuroscience
mtor signaling pathway
Genome-Wide Association Study
Zdroj: International Journal of Molecular Sciences, Vol 21, Iss 5, p 1592 (2020)
International Journal of Molecular Sciences
ISSN: 1422-0067
Popis: Activity-dependent regulation of gene expression is critical in experience-mediated changes in the brain. Although less appreciated than transcriptional control, translational control is a crucial regulatory step of activity-mediated gene expression in physiological and pathological conditions. In the first part of this review, we overview evidence demonstrating the importance of translational controls under the context of synaptic plasticity as well as learning and memory. Then, molecular mechanisms underlying the translational control, including post-translational modifications of translation factors, mTOR signaling pathway, and local translation, are explored. We also summarize how activity-dependent translational regulation is associated with neurodevelopmental and psychiatric disorders, such as autism spectrum disorder and depression. In the second part, we highlight how recent application of high-throughput sequencing techniques has added insight into genome-wide studies on translational regulation of neuronal genes. Sequencing-based strategies to identify molecular signatures of the active neuronal population responding to a specific stimulus are discussed. Overall, this review aims to highlight the implication of translational control for neuronal gene regulation and functions of the brain and to suggest prospects provided by the leading-edge techniques to study yet-unappreciated translational regulation in the nervous system.
Databáze: OpenAIRE
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