Remifentanil and glucose suppress inflammation in a rat model of surgical stress
| Autor: | Takayuki Noguchi, Hideo Iwasaka, Junya Kusaka, Satoshi Hagiwara, Rie Hasegawa, Akira Hasegawa, Nobuhiko Asai, Kyousuke Kudo |
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| Rok vydání: | 2011 |
| Předmět: |
Blood Glucose
Male Methyl Ethers Ringer's Lactate Surgical stress medicine.medical_treatment Remifentanil Inflammation Sevoflurane Quadriceps Muscle Postoperative Complications Piperidines Stress Physiological medicine Animals Hypnotics and Sedatives Phosphorylation Rats Wistar Interleukin-6 Tumor Necrosis Factor-alpha business.industry Forkhead Box Protein O3 Forkhead Transcription Factors General Medicine Perioperative Rats Glucose Cytokine Gluconeogenesis Anesthesia Anesthetics Inhalation Models Animal Surgery Tumor necrosis factor alpha Isotonic Solutions medicine.symptom business Proto-Oncogene Proteins c-akt medicine.drug |
| Zdroj: | Surgery Today. 41:1617-1621 |
| ISSN: | 1436-2813 0941-1291 |
| DOI: | 10.1007/s00595-010-4457-z |
| Popis: | Postoperative stress produces an inflammatory response. Recent studies have shown that narcotic analgesics suppress the immune system. Nutritional management during perioperative care has also been reported to affect inflammation. We therefore examined whether remifentanil or glucose administration could ameliorate postsurgical inflammatory responses using a rat model of surgical stress. We divided male Wistar rats randomly into five groups: (1) control, (2) sevoflurane+lactated Ringer’s solution, (3) sevoflurane+lactated Ringer’s solution with 1% glucose, (4) sevoflurane+remifentanil+lactated Ringer’s solution, and (5) sevoflurane+remifentanil+ lactated Ringer’s solution with 1% glucose. In all groups, serum samples were obtained at various time points after surgery, and secreted cytokine concentrations were determined. In addition, we assessed the activation of protein kinase B (Akt) and forkhead/winged helix box class O (FOXO3), which play a role in gluconeogenesis/stress responses. Surgical stress increased the serum concentrations of tumor necrosis factor-α and interleukin-6. Groups receiving remifentanil with anesthesia showed an attenuated inflammatory response. The inflammatory response was also reduced by administering 1% glucose. Furthermore, 1% glucose induced Akt and FOXO3 phosphorylation in the quadriceps femoris muscle 12 h after surgery. Anesthesia based on remifentanil and perioperative administration of lactated Ringer’s solution containing 1% glucose may be able to control inflammatory responses caused by surgical stress. |
| Databáze: | OpenAIRE |
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