Composites of bone morphogenetic protein (BMP) and type IV collagen, coral-derived coral hydroxyapatite, and tricalcium phosphate ceramics
| Autor: | M. R. Urist, T. S. Lindholm, Aulis Marttinen, Gao Tj |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Calcium Phosphates
Ceramics animal structures Coral chemistry.chemical_element Biocompatible Materials Calcium Bone morphogenetic protein Mice Type IV collagen Osteogenesis medicine Animals Orthopedics and Sports Medicine Muscle Skeletal Chromatography High Pressure Liquid Drug Carriers Ossification business.industry Calcium Radioisotopes Deer Ossification Heterotopic Prostheses and Implants Anatomy Invertebrates In vitro Cell biology Molecular Weight chemistry Bone Morphogenetic Proteins embryonic structures Surgery Collagen Hydroxyapatites Delivery system medicine.symptom business Drug carrier |
| Zdroj: | International Orthopaedics. 20:321-325 |
| ISSN: | 1432-5195 0341-2695 |
| DOI: | 10.1007/s002640050086 |
| Popis: | Few studies have been performed to investigate the characteristics of native Bone Morphogenetic Protein (BMP). We derived 5.85 g of native moose BMP from 102 kg of fresh moose bone and performed chromatographic studies to characterise its structure. We found the BMP molecule to have a molecular weight of 11-700 kDa. To investigate the ideal local delivery system for BMP we used porous discs as a carrier. These were implanted into 132 mice. The volume of new bone formed was evaluated by means of histological specimens, radiographs and isotope studies. The best results were obtained by implanting porous discs (coral and ceramic) with type IV collagen and BMP. We suggest that this is the best delivery system for future experiments regarding the acton of BMP. |
| Databáze: | OpenAIRE |
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