A case of toxic megacolon in ulcerative colitis associated with cytomegalovirus infection
| Autor: | Kenji Koyama, Masahiro Saito, Michiro Otaka, Yuri Saito, Yutaka Shibata, Hitoshi Kotanagi, Osamu Aizawa, Mitsuro Chiba, Takemi Fukuoka, Toshiaki Yoshioka |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
medicine.medical_specialty Toxic megacolon Pathology Abdominal pain Exacerbation Colon Congenital cytomegalovirus infection Opportunistic Infections Megacolon Toxic Colonic Diseases Internal medicine parasitic diseases medicine Humans Intestinal Mucosa Cytomegalic inclusion disease business.industry Gastroenterology Hepatology medicine.disease Ulcerative colitis Cytomegalovirus Infections Colitis Ulcerative Female medicine.symptom business Abdominal surgery |
| Zdroj: | Journal of Gastroenterology. 29:501-505 |
| ISSN: | 1435-5922 0944-1174 |
| DOI: | 10.1007/bf02361250 |
| Popis: | Cytomegalovirus (CMV) infection, which has been shown to complicate the course of ulcerative colitis (UC), has been implicated as a possible etiologic factor in the exacerbation of UC, especially in toxic megacolon. However, CMV infection in patients with UC accompanied by toxic megacolon has rarely been reported. Here we report a case of CMV infection of the colon accompanied by toxic megacolon occurring in UC. A 38-year-old woman had been treated with intravenous hydrocortisone, rectal steroid, and central venous alimentation for 6 weeks under the diagnosis of UC. She was transferred to Akita University Hospital because of increasing bloody diarrhea and abdominal pain. Toxic megacolon was identified by examinations on admission, and she underwent a total colectomy. Examination of the surgical specimen showed severe inflammation of the colon. Microscopically, cytomegalic inclusions were observed in and around the endothelial cells in the inflamed submucosal layer. It can be assumed that CMV infection was a secondary, opportunistic invader superimposed on UC, and that it played an important role in altering the clinical course of the patient. |
| Databáze: | OpenAIRE |
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