Association of CMR-Measured LA Function With Heart Failure Development
| Autor: | Joao A.C. Lima, Anders Opdahl, Susan R. Heckbert, Gregory Hundley, Thomas Helle-Valle, Harjit Chahal, Steven Shea, Colin Wu, Ola Gjesdal, Robyn L. McClelland, Mohammadali Habibi, David A. Bluemke |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
education.field_of_study
medicine.medical_specialty Pathology medicine.diagnostic_test business.industry Population Case-control study Magnetic resonance imaging medicine.disease Asymptomatic Mesa Radiology Nuclear Medicine and imaging Left atrial Internal medicine Heart failure medicine Cardiology Radiology Nuclear Medicine and imaging medicine.symptom Cardiology and Cardiovascular Medicine education business computer computer.programming_language Asymptomatic Diseases |
| Zdroj: | JACC: Cardiovascular Imaging. 7:570-579 |
| ISSN: | 1936-878X |
| DOI: | 10.1016/j.jcmg.2014.01.016 |
| Popis: | Objectives The goal of this study was to assess the association between left atrial (LA) volume and function measured with feature-tracking cardiac magnetic resonance (CMR) and development of heart failure (HF) in asymptomatic individuals. Background Whether alterations of LA structure and function precede or follow HF development remains incompletely understood. We hypothesized that significant alterations of LA deformation and architecture precede the development of HF in the general population. Methods In a case-control study nested in MESA (Multi-Ethnic Study of Atherosclerosis), baseline LA volume and function assessed using CMR feature-tracking were compared between 112 participants with incident HF (mean age 68.4 ± 8.2 years; 66% men) and 224 age- and sex-matched controls (mean age 67.7 ± 8.9 years; 66% men). Participants were followed up for 8 years. All individuals were in normal sinus rhythm at the time of imaging, without any significant valvular abnormalities and free of clinical cardiovascular diseases. Results Individuals with incident HF had greater maximal and minimal LA volume indexes (LAVImin) than control subjects (40 ± 13 mm3/m2 vs. 33 ± 10 mm3/m2 [p Conclusions Deteriorations in LA structure and function preceded development of HF. Lower global PLAS and higher LAVImin, measured using CMR feature-tracking, were independent markers of incident HF in a multiethnic population of asymptomatic individuals. |
| Databáze: | OpenAIRE |
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