High prevalence of pulmonary embolism prior to cancer therapies in patients with ovarian and endometrial cancers detected by contrast-enhanced CT using D-dimer as an index
| Autor: | Shinsuke Hanawa, Takuro Horikoshi, Makio Shozu, Hirokazu Usui, Akira Mitsuhashi, Takashi Uno, Yuji Habu |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
medicine.medical_specialty Enhanced ct Gastroenterology Sensitivity and Specificity Fibrin Fibrinogen Degradation Products 03 medical and health sciences 0302 clinical medicine Internal medicine D-dimer medicine Prevalence Humans In patient cardiovascular diseases Aged Aged 80 and over Ovarian Neoplasms Venous Thrombosis business.industry Endometrial cancer Cancer General Medicine Venous Thromboembolism Middle Aged medicine.disease Pulmonary embolism Endometrial Neoplasms Venous thrombosis Oncology 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Surgery Female Ovarian cancer business Pulmonary Embolism Tomography X-Ray Computed |
| Zdroj: | Journal of surgical oncologyREFERENCES. 124(1) |
| ISSN: | 1096-9098 |
| Popis: | Objective We aimed to evaluate the prevalence of pulmonary embolism (PE) before cancer therapies in patients with ovarian and endometrial cancers with enhanced computed tomography (CT) using D-dimer (DD), and determine the optimal cut-off level of DD. Methods Since 2009, we have performed preoperative venous thromboembolism (VTE) screening of patients with ovarian and endometrial cancer. For patients with DD levels of more than 1.0 μg/ml, enhanced CT images were obtained from the pulmonary apex to the foot to detect PE and deep venous thrombosis (DVT) simultaneously. Results Among patients with ovarian cancer, 84 of 413 (20.3%) had VTEs (DVT alone, n = 31 [7.5%]; PE with or without DVT, n = 53 [12.8%]; PE alone, n = 12 [2.9%]). Among patients with endometrial cancer, 50 of 455 (11.0%) had VTEs (DVT alone, n = 19 [4.2%]; PE with or without DVT, n = 31 [6.8%], PE alone, n = 14 [3.1%]). The optimal cut-off level of DD was estimated to be ≥1.5 and ≥1.2 μg/ml in ovarian and endometrial cancers, respectively. Conclusion Our study revealed a high prevalence of PE before cancer therapies in patients with ovarian and endometrial cancers by enhanced CT using DD. |
| Databáze: | OpenAIRE |
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