Novel biomarkers for the assessment of paediatric systemic lupus erythematosus nephritis

Autor:	Artemis Koutsonikoli, Maria Trachana, Alexandros Garyphallos, Nikoleta Printza, V. Galanopoulou, Fotios Papachristou, V Tzimouli, F Kanakoudi-Tsakalidou, Evangelia Farmaki, Polyxeni Pratsidou-Gertsi
Rok vydání:	2017
Předmět:	Adult Male 0301 basic medicine endocrine system Adolescent Immunology Lupus nephritis chemical and pharmacologic phenomena Complement factor I HMGB1 Severity of Illness Index Young Adult 03 medical and health sciences 0302 clinical medicine medicine Humans Immunology and Allergy Age of Onset HMGB1 Protein Child skin and connective tissue diseases Autoantibodies 030203 arthritis & rheumatology biology business.industry Complement C1q Autoantibody Original Articles medicine.disease Lupus Nephritis 030104 developmental biology Case-Control Studies Child Preschool biology.protein Biomarker (medicine) Female Antibody business Nephritis Biomarkers Anti-SSA/Ro autoantibodies
Zdroj:	Clinical and Experimental Immunology. 188:79-85
ISSN:	1365-2249 0009-9104
DOI:	10.1111/cei.12913
Popis:	Summary The discovery of serum biomarkers specific for paediatric lupus nephritis (pLN) will facilitate the non-invasive diagnosis, follow-up and more appropriate use of treatment. The aim of this study was to explore the role of serum high-mobility group box 1 (HMGB1) protein, antibodies against nucleosomes (anti-NCS), complement factor C1q (anti-C1q) and glomerular basement membrane (anti-GBM) in pLN. Serum samples of 42 patients with paediatric systemic lupus erythematosus (pSLE) (22 with pLN and 20 without renal involvement), 15 patients with other autoimmune nephritis (AN) and 26 healthy controls (HCs) were examined using enzyme-linked immunosorbent assay (ELISA). The activity of both pSLE and pLN was assessed by the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) tool. The levels of all four biomarkers were significantly higher in pLN compared to AN and to HCs. The anti-NCS, anti-GBM and HMGB1 serum levels were significantly higher in pLN than in pSLE without renal involvement. The anti-C1q and the HMGB1 serum levels were correlated positively with pSLE activity. The HMGB1 serum levels were also correlated positively with pLN activity. These findings suggest that serum anti-NCS, anti-GBM and HMGB1 may serve as biomarkers specific for the presence of nephritis in pSLE. HMGB1 emerged as a useful biomarker for the assessment of pLN and pSLE activity, whereas anti-C1q only of pSLE activity.
Databáze:	OpenAIRE
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