Studies on cephalosporin antibiotics. I. Synthesis, antibacterial activity and oral absorption of new 3-(O-substituted)-7.BETA.-(D-.ALPHA.-amino-.ALPHA.-(4-hydroxyphenyl)acetamido)cephalosporins
| Autor: | Chihiro Yokoo, Mitsuo Murata, Kaoru Sota, Takatoshi Nagate, Yoshiaki Watanabe, Masami Goi, Akira Onodera |
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| Rok vydání: | 1988 |
| Předmět: |
Male
Magnetic Resonance Spectroscopy Chemical Phenomena Spectrophotometry Infrared medicine.drug_class Stereochemistry Cephalosporin Administration Oral Microbial Sensitivity Tests Structure-Activity Relationship chemistry.chemical_compound Drug Discovery polycyclic compounds medicine Animals Cephalosporin Antibiotic Antibacterial agent Pharmacology Bicyclic molecule biology Biological activity biology.organism_classification Cephalosporins Rats Chemistry Intestinal Absorption chemistry Lactam Antibacterial activity Bacteria |
| Zdroj: | The Journal of Antibiotics. 41:170-180 |
| ISSN: | 1881-1469 0021-8820 |
| Popis: | The synthesis, antibacterial activity and oral absorption of new 7 beta-[D-alpha-amino-alpha-(4-hydroxyphenyl)acetamido]cephalosporins (1) with various O-substituents at the C-3 position of a cephalosporin nucleus are described. Of these, the cephalosporins (1b-1e) having an alkoxycarbonylmethoxy group at the C-3 position showed good oral absorption in rats as well as potent activity against Gram-positive bacteria. The structure-activity relationships of 1 are also presented. |
| Databáze: | OpenAIRE |
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