Neurotrophic and inflammatory markers in bipolar disorder : a prospective study
Autor: | Bernard Sabbe, Violette Coppens, Jeroen Schuermans, Peter de Boer, Erik Fransen, Manuel Morrens, Seline van den Ameele, Maarten Timmers |
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Přispěvatelé: | Psychiatry, Faculty of Medicine and Pharmacy, Cell Biology and Histology, Clinical sciences, Neuroprotection & Neuromodulation, Clinical and Lifespan Psychology |
Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
Male
Vascular Endothelial Growth Factor A Oncology Bipolar Disorder Endocrinology Diabetes and Metabolism Inflammatory markers a propective study 0302 clinical medicine Endocrinology Neurotrophic factors Prospective Studies Prospective cohort study Medicine(all) biology Middle Aged Psychiatry and Mental health Neurotrophic Disease Progression Biomarker (medicine) Female Psychology Neurotrophin Adult medicine.medical_specialty 03 medical and health sciences Internal medicine Neuroplasticity Journal Article medicine Humans Bipolar disorder Biological Psychiatry Brain-derived neurotrophic factor Tumor necrosis factor alpha (TNF-α) Vascular Endothelial Growth Factor Receptor-1 Tumor Necrosis Factor-alpha Endocrine and Autonomic Systems Brain-Derived Neurotrophic Factor Vascular endothelial growth factor (VEGF) medicine.disease Soluble fms-like tyrosine kinase-1 (sFlt-1) 030227 psychiatry Mood inflammation Case-Control Studies biology.protein Human medicine Biomarkers 030217 neurology & neurosurgery |
Zdroj: | Psychoneuroendocrinology |
ISSN: | 0306-4530 |
Popis: | Altered neurotrophic signaling is thought to impair neuroplasticity in bipolar disorder (BD). Brain-derived neurotrophic factor (BDNF) is proposed as a neurotrophic marker in BD. However, the current evidence for its use in monitoring disease activity and illness progression is conflicting and an exploration of additional neurotrophic markers is needed. This prospective case-control study investigated mood-specific changes in potential neurotrophic markers and their association to inflammatory activity. Patients with BD were included during an acute mood episode, either depressive (n=35) or (hypo)manic (n=32). Fifty-nine patients (88%) and 29 healthy controls (97%) completed the study. Peripheral blood levels of BDNF, vascular endothelial growth factor A (VEGF), soluble fms-like tyrosine kinase-1 (sFlt-1) and tumor necrosis factor alpha (TNF-α) were measured at baseline and after 2 months. Biomarker levels in patients were compared to controls and correlated to HDRS-17 and YMRS total scores and the PANSS positive subscale scores. Linear mixed model analysis revealed no significant differences in neurotrophic markers between patients and controls. We found significantly increased TNF-α levels in patients and a subsequent normalization during euthymia. None of the biomarkers strongly correlated to mood symptom severity. Despite standardized methodological practices, BDNF and VEGF levels had a wide distribution range. We need a better understanding of methodological aspects influencing the analysis of neurotrophic factors to improve future research on markers for mood state monitoring and illness progression in BD. |
Databáze: | OpenAIRE |
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