Neurotrophic and inflammatory markers in bipolar disorder : a prospective study

Autor: Bernard Sabbe, Violette Coppens, Jeroen Schuermans, Peter de Boer, Erik Fransen, Manuel Morrens, Seline van den Ameele, Maarten Timmers
Přispěvatelé: Psychiatry, Faculty of Medicine and Pharmacy, Cell Biology and Histology, Clinical sciences, Neuroprotection & Neuromodulation, Clinical and Lifespan Psychology
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Male
Vascular Endothelial Growth Factor A
Oncology
Bipolar Disorder
Endocrinology
Diabetes and Metabolism
Inflammatory markers
a propective study
0302 clinical medicine
Endocrinology
Neurotrophic factors
Prospective Studies
Prospective cohort study
Medicine(all)
biology
Middle Aged
Psychiatry and Mental health
Neurotrophic
Disease Progression
Biomarker (medicine)
Female
Psychology
Neurotrophin
Adult
medicine.medical_specialty
03 medical and health sciences
Internal medicine
Neuroplasticity
Journal Article
medicine
Humans
Bipolar disorder
Biological Psychiatry
Brain-derived neurotrophic factor
Tumor necrosis factor alpha (TNF-α)
Vascular Endothelial Growth Factor Receptor-1
Tumor Necrosis Factor-alpha
Endocrine and Autonomic Systems
Brain-Derived Neurotrophic Factor
Vascular endothelial growth factor (VEGF)
medicine.disease
Soluble fms-like tyrosine kinase-1 (sFlt-1)
030227 psychiatry
Mood
inflammation
Case-Control Studies
biology.protein
Human medicine
Biomarkers
030217 neurology & neurosurgery
Zdroj: Psychoneuroendocrinology
ISSN: 0306-4530
Popis: Altered neurotrophic signaling is thought to impair neuroplasticity in bipolar disorder (BD). Brain-derived neurotrophic factor (BDNF) is proposed as a neurotrophic marker in BD. However, the current evidence for its use in monitoring disease activity and illness progression is conflicting and an exploration of additional neurotrophic markers is needed. This prospective case-control study investigated mood-specific changes in potential neurotrophic markers and their association to inflammatory activity. Patients with BD were included during an acute mood episode, either depressive (n=35) or (hypo)manic (n=32). Fifty-nine patients (88%) and 29 healthy controls (97%) completed the study. Peripheral blood levels of BDNF, vascular endothelial growth factor A (VEGF), soluble fms-like tyrosine kinase-1 (sFlt-1) and tumor necrosis factor alpha (TNF-α) were measured at baseline and after 2 months. Biomarker levels in patients were compared to controls and correlated to HDRS-17 and YMRS total scores and the PANSS positive subscale scores. Linear mixed model analysis revealed no significant differences in neurotrophic markers between patients and controls. We found significantly increased TNF-α levels in patients and a subsequent normalization during euthymia. None of the biomarkers strongly correlated to mood symptom severity. Despite standardized methodological practices, BDNF and VEGF levels had a wide distribution range. We need a better understanding of methodological aspects influencing the analysis of neurotrophic factors to improve future research on markers for mood state monitoring and illness progression in BD.
Databáze: OpenAIRE
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