Dietary stearic acid regulates mitochondria in vivo in humans
| Autor: | Aurelio A. Teleman, Peter P. Nawroth, Martina U. Muckenthaler, Thomas Fleming, Daniel Pfaff, Kathrin V. Schwarz, Deniz Senyilmaz-Tiebe, Sandro Altamura, Sam Virtue, Antonio Vidal-Puig, Jürgen G. Okun |
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| Přispěvatelé: | Senyilmaz-Tiebe, Deniz [0000-0002-2976-1204], Muckenthaler, Martina U [0000-0002-3778-510X], Teleman, Aurelio A [0000-0002-4237-9368], Apollo - University of Cambridge Repository |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Male Metabolite Science General Physics and Astronomy Mitochondrion Mitochondrial Dynamics General Biochemistry Genetics and Molecular Biology Article Beverages 03 medical and health sciences chemistry.chemical_compound In vivo Carnitine Sense (molecular biology) Diabetes Mellitus Ingestion Humans lcsh:Science chemistry.chemical_classification Multidisciplinary Cross-Over Studies Fatty Acids Fatty acid food and beverages Musa General Chemistry Middle Aged equipment and supplies 3. Good health Cell biology Diet Mitochondria Oxygen 030104 developmental biology chemistry mitochondrial fusion Case-Control Studies lcsh:Q lipids (amino acids peptides and proteins) Female Stearic acid Stearic Acids |
| Zdroj: | Nature Communications Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018) Nat. Commun. 9:3129 (2018) |
| ISSN: | 2041-1723 |
| Popis: | Since modern foods are unnaturally enriched in single metabolites, it is important to understand which metabolites are sensed by the human body and which are not. We previously showed that the fatty acid stearic acid (C18:0) signals via a dedicated pathway to regulate mitofusin activity and thereby mitochondrial morphology and function in cell culture. Whether this pathway is poised to sense changes in dietary intake of C18:0 in humans is not known. We show here that C18:0 ingestion rapidly and robustly causes mitochondrial fusion in people within 3 h after ingestion. C18:0 intake also causes a drop in circulating long-chain acylcarnitines, suggesting increased fatty acid beta-oxidation in vivo. This work thereby identifies C18:0 as a dietary metabolite that is sensed by our bodies to control our mitochondria. This could explain part of the epidemiological differences between C16:0 and C18:0, whereby C16:0 increases cardiovascular and cancer risk whereas C18:0 decreases both. Dietary fatty acids have different effects on human health. Here, the authors show that ingestion of the fatty acid C18:0, but not of C16:0, rapidly leads to fusion of mitochondria and fatty acid oxidation in humans, possibly explaining the health benefits of C18:0. |
| Databáze: | OpenAIRE |
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