Urinary Soluble VCAM-1 is a Useful Biomarker of Disease Activity and Treatment Response in Lupus Nephritis
| Autor: | Pedro Guilherme Schaefer, Odirlei André Monticielo, Marina Siebert, Andrese Aline Gasparin, Nicole Pamplona Bueno de Andrade, Vanessa Hax, Francisco José Veríssimo Veronese, Penelope Esther Palominos, Romulo Marx |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Tratamento lcsh:Diseases of the musculoskeletal system Vascular cell adhesion molecule-1 Urinary system Prognóstico Lupus nephritis Urine Gastroenterology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Rheumatology Molécula 1 de adesão de célula vascular Internal medicine Medicine VCAM-1 Prospective cohort study 030203 arthritis & rheumatology business.industry medicine.disease Nefrite lúpica 030104 developmental biology Biomarcadores chemistry Urinary biomarker Biomarker (medicine) lcsh:RC925-935 business Nephritis Research Article |
| Zdroj: | BMC Rheumatology, Vol 4, Iss 1, Pp 1-10 (2020) BMC Rheumatology Repositório Institucional da UFRGS Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
| DOI: | 10.21203/rs.3.rs-35503/v1 |
| Popis: | Introduction Vascular cell adhesion molecule-1 (VCAM-1) is involved in the progression of glomerular and tubulointerstitial injury in lupus nephritis (LN) and can be easily assessed in urine. The aim of this study was to assess urinary soluble VCAM-1 (uVCAM-1) as a biomarker of disease activity and treatment response in LN. Methods This prospective study enrolled 62 patients with class III, IV or V LN diagnosed within the last 3 years and divided them in two groups: with and without active nephritis at the inclusion, each group with 31 patients. At each visit, a urine sample was collected for uVCAM-1 evaluation and the nephritis status was assessed. Results Median uVCAM-1 level was elevated in patients with active compared to inactive LN (P P P = 0.002) and did not change in patients who remained inactive (P = 0.797). The level of uVCAM-1 peaked during the flare of LN (P Conclusion The uVCAM-1 is a reliable biomarker that reflects renal disease activity and is useful for monitoring individual patients with lupus nephritis over time. |
| Databáze: | OpenAIRE |
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