Factors predicting response of end stage squamous cell carcinoma of the head and neck to cisplatinum
| Autor: | Randall P. Morton, F. Rugman, P. J. Stoney, Timothy R. Helliwell, J. Miles, P. M. Stell, J. B. Campbell, E. B. Dorman, M. S. McCORMICK, E. D. Vaughan, Wilson Ja |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Oncology
medicine.medical_specialty medicine.medical_treatment Disease Bleomycin Random Allocation chemistry.chemical_compound Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Stage (cooking) Clinical Trials as Topic Chemotherapy Performance status business.industry Head and neck cancer medicine.disease Combined Modality Therapy Squamous carcinoma Methotrexate Otorhinolaryngology chemistry Head and Neck Neoplasms Carcinoma Squamous Cell Fluorouracil Cisplatin Neoplasm Recurrence Local business Follow-Up Studies medicine.drug |
| Zdroj: | Clinical Otolaryngology. 12:167-176 |
| ISSN: | 1749-4486 1749-4478 |
| DOI: | 10.1111/j.1365-2273.1987.tb00183.x |
| Popis: | Cisplatinum significantly prolongs survival in end stage head and neck cancer but only 30-40% of patients respond. Many receive chemotherapy with little or no benefit and it would obviously be advantageous to determine in advance those patients likely to benefit. In 2 phase III trials of chemotherapy in end stage disease, 129 patients have been treated with cisplatinum, either alone or in 2-drug combination with bleomycin, methotrexate or 5-fluorouracil. Factors analysed in the entire group were age, sex, site, previous treatment, performance status and the use of cisplatinum in combination. A high albumen and oro- or nasopharyngeal site were significantly favourable, while a hypopharyngeal, middle ear, skin or paranasal site were all significantly unfavourable. In the separate analysis of the subgroup with recurrent disease, site of recurrence and time to recurrence were analysed in addition to the factors named above. Although similar trends to those in the entire group were observed none reached significant levels. In the subgroup with advanced previously untreated disease, histological grade was analysed in addition to the above factors. Good performance status emerged as significantly favourable. The emerging trends provide some insight regarding outcome but are not sufficiently clearcut to allow a decision to be made on who should and who should not be treated. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|