Satigrel, a New Antiplatelet Agent, Inhibits Platelet Accumulation in Prosthetic Arterial Grafts
| Autor: | Katsumi Ishii, Hatsuzo Uchida, Hiroshi Shigematsu, Kensuke Esato, Keishu Yasuda, Takehisa Iwai, Yoshihiko Kubo, Shin Ishimaru |
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| Rok vydání: | 1998 |
| Předmět: |
Blood Platelets
Male medicine.medical_specialty Time Factors Femoral artery Scintigraphy Fatty Acids Monounsaturated Oral administration medicine.artery medicine Humans Platelet Radionuclide Imaging Aged Arteriosclerosis obliterans medicine.diagnostic_test Polyethylene Terephthalates business.industry Vascular disease Indium Radioisotopes Arteriosclerosis Obliterans General Medicine Middle Aged medicine.disease Blood Vessel Prosthesis Prosthesis Failure Surgery Arterial grafts surgical procedures operative medicine.anatomical_structure Data Interpretation Statistical business Platelet Aggregation Inhibitors Artery |
| Zdroj: | The American Journal of Surgery. 175:56-60 |
| ISSN: | 0002-9610 |
| DOI: | 10.1016/s0002-9610(97)00224-9 |
| Popis: | Background: Early and late vascular obstruction are both related to platelet adhesion and aggregation in the grafts. We assessed the effect of satigrel, a new oral antiplatelet agent, on the accumulation of indium-labeled platelets in knitted Dacron grafts inserted proximal to the femoral artery. Methods: Nine patients with arteriosclerosis obliterans receiving grafts were treated with satigrel, and 10 others were enrolled as untreated controls. Scintigraphy was performed in postoperative weeks 2 and 4, and the ratio of the scintillation count of the graft to that of the native artery was calculated to assess platelet accumulation. Results: In both weeks 2 and 4, the ratio was significantly smaller in the satigrel group than in the control group for the whole graft, the proximal anastomosis, and the distal anastomosis. Conclusions: Satigrel significantly inhibited platelet accumulation in vascular grafts and thus may be useful for preventing postoperative graft occlusion. |
| Databáze: | OpenAIRE |
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