Physiologic characterization of inflammatory arthritis in a rabbit model with BOLD and DCE MRI at 1.5 Tesla
| Autor: | Anguo Zhong, Garry Detzler, Rahim Moineddin, Michael Chan, Andrea S. Doria, George Nathanael, Ruth Weiss, Hai-Ling Cheng, Roland Jong, Adrian P. Crawley, Tammy Rayner, Jaques Belik, Otilia C. Nasui, Elka Miller, Marianne Rogers, Andrea Kassner |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Knee Joint Inflammatory arthritis Arthritis Contrast Media Osteoarthritis Severity of Illness Index Injections Intra-Articular medicine Laser-Doppler Flowmetry Animals Radiology Nuclear Medicine and imaging Range of Motion Articular skin and connective tissue diseases Neuroradiology Blood-oxygen-level dependent medicine.diagnostic_test business.industry Magnetic resonance imaging General Medicine Blood flow Osteoarthritis Knee medicine.disease Magnetic Resonance Imaging Oxygen Disease Models Animal Radiology Rabbits business Perfusion |
| Zdroj: | European radiology. 24(11) |
| ISSN: | 1432-1084 |
| Popis: | Our aim was to test the feasibility of blood oxygen level dependent magnetic resonance imaging (BOLD MRI) and dynamic contrast-enhanced (DCE) MRI to monitor periarticular hypoxic/inflammatory changes over time in a juvenile rabbit model of arthritis. We examined arthritic and contralateral nonarthritic knees of 21 juvenile rabbits at baseline and days 1,14, and 28 after induction of arthritis by unilateral intra-articular injection of carrageenin with BOLD and DCE MRI at 1.5 Tesla (T). Nine noninjected rabbits served as controls. Associations between BOLD and DCE-MRI and corresponding intra-articular oxygen pressure (PO2) and blood flow [blood perfusion units (BPU)] (polarographic probes, reference standards) or clinical–histological data were measured by correlation coefficients. Percentage BOLD MRI change obtained in contralateral knees correlated moderately with BPU on day 0 (r = −0.51, p = 0.02) and excellently on day 28 (r = −0.84, p = 0.03). A moderate correlation was observed between peak enhancement DCE MRI (day 1) and BPU measurements in arthritic knees (r = 0.49, p = 0.04). In acute arthritis, BOLD and DCE MRI highly correlated (r = 0.89, p = 0.04; r = 1.0, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink