Increased Interleukin-8 in Epithelial Lining Fluid of Collapsed Lungs During One-Lung Ventilation for Thoracotomy
| Autor: | Yoshitaka Yamazaki, Kazuo Yoshida, Tomonobu Koizumi, Joh Hasegawa, Hiroshi Yamamoto, Keishi Kubo, Shino Furuya, Masanori Yasuo, Ryuichi Kondo, Yoshimichi Komatsu, Kenji Tsushima, Sumiko Yoshikawa, Takashi Eguchi |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Pulmonary Atelectasis medicine.medical_specialty ARDS Lung Neoplasms medicine.medical_treatment Interleukin-1beta Immunology Pulmonary Edema Respiratory Mucosa permeability pulmonary edema re-expansion pulmonary edema Lung injury Collapsed Lung Albumins Humans Immunology and Allergy Medicine Thoracotomy Lung Aged Inflammation bronchoscopic microsampling Interleukin-6 Tumor Necrosis Factor-alpha business.industry Interleukin-8 Interleukin Middle Aged respiratory system medicine.disease thoracic surgery One-Lung Ventilation respiratory tract diseases medicine.anatomical_structure Cardiothoracic surgery Anesthesia Breathing Female business |
| Zdroj: | Inflammation. 35:1844-1850 |
| ISSN: | 1573-2576 0360-3997 |
| Popis: | The present study was designed to evaluate inflammatory changes in collapsed lungs during one-lung ventilation using the assistance of a bronchoscopic microsampling probe. Serial albumin and interleukin (IL)-8 concentrations in epithelial lining fluid (ELF) were measured in seven patients undergoing resection of lung tumors. The samples were taken after induction of anesthesia (baseline), 30 min after one-lung ventilation was started (point 2), just before resuming two-lung ventilation (point 3), and 30 min after two-lung ventilation was restarted (point 4). The albumin and IL-8 concentrations in ELF were significantly increased at point 2 and point 3, respectively, and remained to be high, compared to the baseline. The increase in IL-8 at point 3 was correlated with the interval of one-lung ventilation; however, none developed specific acute lung injury. These findings suggest that inflammatory changes can occur on the epithelium of a collapsed lung even in patients who underwent successful and standard thoracic surgery. Article INFLAMMATION. 35(6):1844-1850 (2012) |
| Databáze: | OpenAIRE |
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