Magnetic Resonance Imaging and Anatomical Correlation of Human Temporal Lobe Landmarks, in 3D Euclidean Space: A Study of Control and Alzheimer’s Disease Subjects
| Autor: | Francisco Mansilla-Legorburo, José‐Carlos Delgado‐González, Ricardo Insausti, José Florensa-Vila, Emilio Artacho-Pérula |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Aging tau Proteins Hippocampal formation 050105 experimental psychology Temporal lobe Diagnosis Differential Correlation Young Adult 03 medical and health sciences 0302 clinical medicine Discriminative model Alzheimer Disease medicine Humans 0501 psychology and cognitive sciences Control (linguistics) Aged Aged 80 and over Observer Variation medicine.diagnostic_test Euclidean space General Neuroscience Dentate gyrus 05 social sciences Reproducibility of Results Magnetic resonance imaging Organ Size General Medicine Anatomy Middle Aged Immunohistochemistry Magnetic Resonance Imaging Temporal Lobe Psychiatry and Mental health Clinical Psychology Female Geriatrics and Gerontology Psychology Neuroscience psychological phenomena and processes 030217 neurology & neurosurgery |
| Zdroj: | Journal of Alzheimer's Disease. 57:461-473 |
| ISSN: | 1875-8908 1387-2877 |
| Popis: | Background The medial temporal lobe (MTL), and in particular the hippocampal formation, is essential in the processing and consolidation of declarative memory. The 3D environment of the anatomical structures contained in the MTL is an important issue. Objective Our aim was to explore the spatial relationship of the anatomical structures of the MTL and changes in aging and/or Alzheimer's disease (AD). Methods MTL anatomical landmarks are identified and registered to create a 3D network. The brain network is quantitatively described as a plane, rostrocaudally-oriented, and presenting Euclidean/real distances. Correspondence between 1.5T RM, 3T RM, and histological sections were assessed to determine the most important recognizable changes in AD, based on statistical significance. Results In both 1.5T and 3T RM images and histology, inter-rater reliability was high. Sex and hemisphere had no influence on network pattern. Minor changes were found in relation to aging. Distances from the temporal pole to the dentate gyrus showed the most significant differences when comparing control and AD groups. The best discriminative distance between control and AD cases was found in the temporal pole/dentate gyrus rostrocaudal length in histological sections. Moreover, more distances between landmarks were required to obtain 100% discrimination between control (divided into 65 years) and AD cases. Discussion Changes in the distance between MTL anatomical landmarks can successfully be detected by using measurements of 3D network patterns in control and AD cases. |
| Databáze: | OpenAIRE |
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