THE PREOPTIC ANTERIOR HYPOTHALAMIC AREA MEDIATES INITIATION OF THE HYPOTENSIVE RESPONSE INDUCED BY LPS IN MALE RATS
| Autor: | William R. Millington, Carlos Feleder, Mustafa Sertac Yilmaz |
|---|---|
| Přispěvatelé: | Uludağ Üniversitesi/Tıp Fakültesi/Farmakoloji ve Klinik Farmakoloji Anabilim Dalı., Yılmaz, Mustafa Sertaç, AAH-1571-2021 |
| Rok vydání: | 2008 |
| Předmět: |
Lipopolysaccharides
Male Lidocaine Lateral hypothalamus Blood Pressure Critical Care and Intensive Care Medicine Animal tissue Rats Sprague-Dawley Nitric-oxide Endotoxin Mediator release Septic shock Medicine Regulatory mechanism Anterior hypothalamicnucleus Sickness behavior Inhibition Arterial pressure Hematology Brain Neural mechanism Peripheral Emergency Medicine Hypotension Halothane Animal cell medicine.drug endocrine system medicine.medical_specialty Fever Hypothalamus Periaqueductal gray Lipopolysaccharide Nucleus Article Internal medicine Animals Critical care medicine Illness Behavior Leukocyte Endogenous Mediator Antipyretics Animal model Animal experiment Endotoxic shock Inflammation Systemic inflammation Tumor necrosis factor alpha Tumor Necrosis Factor-alpha business.industry medicine.disease Cardiovascular function Rats Blockade Cardiovascular system & cardiology Blood pressure Endocrinology Stimulation Peripheral vascular disease Rat Surgery Alpha-msh General & internal medicine Preoptic area Anterior Hypothalamic Nucleus business Controlled study |
| Zdroj: | Shock. 29:232-237 |
| ISSN: | 1073-2322 |
| DOI: | 10.1097/shk.0b013e3180caac7e |
| Popis: | The mechanism responsible for the initiation of endotoxic hypotension is not fully understood, although it is often attributed to a direct effect of LPS and other vasoactive mediators on the vasculature. Alternatively, recent evidence raises the possibility that endotoxic hypotension may be initiated through a central mechanism. Previous studies have shown that LPS initiates fever, sickness behavior, and other aspects of the inflammatory response through a neural pathway that sends peripheral inflammatory signals to the preoptic anterior hypothalamic area (POA). It is also well known that the POA plays a role in the regulation of cardiovascular function, but its involvement in LPS-induced hypotension has not been examined previously. Therefore, the aim of the present paper was to investigate whether the initial abrupt fall in arterial pressure evoked by LPS in septic shock is mediated by the POA. LPS (1 mg/kg, im.) administration to halothane-anesthetized or conscious rats lowered arterial blood pressure by 24.8 +/- 2.9 and 25.1 +/- 5.8 mmHg, respectively. Bilateral lidocaine (2%; 1 mu L) injection into the POA, but not the lateral hypothalamus, prevented the hypotension evoked by LPS entirely in both anesthetized and conscious animals. Remarkably, this blockade significantly inhibited the second, delayed fall in arterial pressure induced by LPS, and simultaneously decreased TNF-alpha plasma levels. Together, these data indicate that the initial phase of endotoxic hypotension is mediated by the POA and suggest that the initiation of the hypotensive response induced by LPS can be essential for the development of the late fall in blood pressure. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|