LABORAS™: Initial pharmacological validation of a system allowing continuous monitoring of laboratory rodent behaviour
| Autor: | Brenda K. Trail, Sharon C Stratton, Leann P. Quinn, Andrew Billinton, Mark S. Duxon, Tania O. Stean, Neil Upton |
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| Rok vydání: | 2003 |
| Předmět: |
Male
Indoles Pyridines Behavioural analysis Aminopyridines Motor Activity Pharmacology Locomotor activity Piperazines Rats Sprague-Dawley Receptor Serotonin 5-HT2C Haloperidol medicine Animals Amphetamine Injections Intraventricular 8-Hydroxy-2-(di-n-propylamino)tetralin Psychotropic Drugs Behavior Animal Psychology Experimental Angiotensin II General Neuroscience Continuous monitoring Feeding Behavior Rats Serotonin Receptor Agonists Sprague dawley Receptor Serotonin 5-HT1A Central Nervous System Stimulants Serotonin Antagonists Psychology Neuroscience Antipsychotic Agents medicine.drug |
| Zdroj: | Journal of Neuroscience Methods. 130:83-92 |
| ISSN: | 0165-0270 |
| Popis: | A newly developed apparatus for automated behavioural analysis, Laboratory Animal Behaviour Observation, Registration and Analysis System (LABORAS), has been further validated with respect to the ability of the system to detect the pharmacodynamic effects of standard pharmacological tools. Data were obtained from rats administered with mCPP (reversal with SB242084), 8-OH-DPAT (reversal with WAY100635), amphetamine (reversal with haloperidol) and angiotensin, with the focus on locomotor activity, feeding and drinking behaviours. The data captured and analysed by LABORAS, suggests that the automated system is able to detect pharmacologically induced changes in behaviour, reliably and efficiently, with a significant reduction in the number of animals required, and reduced operator input. |
| Databáze: | OpenAIRE |
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