A multi-center, controlled, randomized, open-label clinical study of levofloxacin for preventing infection during the perioperative period of ultrasound-guided transrectal prostate biopsy
| Autor: | W. Tang, Yijin Zhang, Shan Chen, X.-D. Zhang, X.-F. Gao, Xiao-feng Wang, L.-D. Qiao, Y.-J. Niu, Yan-qun Na, W.-M. Yang, B.-K. Shi, Zhigang Chen, Jian Wang, C.-Z. Kong |
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| Rok vydání: | 2016 |
| Předmět: |
Image-Guided Biopsy
Male Microbiology (medical) China medicine.medical_specialty 030232 urology & nephrology Administration Oral Levofloxacin Preoperative care law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Preoperative Care medicine Humans Prospective Studies 030212 general & internal medicine Antibiotic prophylaxis Prospective cohort study Aged Aged 80 and over business.industry Incidence Incidence (epidemiology) Prostatic Neoplasms Bacterial Infections General Medicine Perioperative Antibiotic Prophylaxis Middle Aged medicine.disease Anti-Bacterial Agents Surgery Treatment Outcome Infectious Diseases Bacteremia Original Article Administration Intravenous business medicine.drug |
| Zdroj: | European Journal of Clinical Microbiology & Infectious Diseases |
| ISSN: | 1435-4373 0934-9723 |
| DOI: | 10.1007/s10096-016-2742-5 |
| Popis: | By comparing the safety and efficacy of 500 mg of oral levofloxacin for 3 days with those of intravenous antibiotics for 3 days in the prevention of infectious complications of ultrasound-guided transrectal prostate biopsy (TPB), we provided a safe and cost-effective infection preventive protocol for TPB in China. A total of 801 patients with indications for TPB in 12 centers were randomized into two groups from October 2011 to December 2015. Patients in the test group (n = 392) took 500 mg of oral levofloxacin for 3 days. Patients in the control group (n = 409) underwent intravenous antibiotics according to the traditional habits of the center for 3 days. All patients underwent ultrasound-guided TPB. Infectious complications were compared between the two groups. Different kinds of antibiotic were used in the control group. Comparing the two groups, the mean patient age was 70.6 ± 14.0 and 70.5 ± 14.0 years. The incidence of total infectious complications was 4.6 % (18/392) and 4.4 % (18/409) respectively, the incidence of asymptomatic bacteriuria was 3.1 % (12/392) and 2.7 % (11/409), the incidence of symptomatic urinary tract infection was 0.0 % and 0.2 % (1/409), the incidence of fever was 0.8 % (3/392) and 0.5 % (2/409), the incidence of bacteremia was 0.5 % (2/392) and 0.0 %, and the incidence of urosepsis was 0.3 % (1/392) and 1.0 % (4/409) respectively (all P > 0.05). The selection of antibacterial agents for TPB is in ca haotic condition in China. Oral levofloxacin at 500 mg once daily for 3 days is a safe, convenient, and cost-effective infection preventive protocol for TPB in China. |
| Databáze: | OpenAIRE |
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