Oxidative stress in opium users after using lead-adulterated opium: The role of genetic polymorphism
| Autor: | Saeedeh Shojaeepour, Zohreh Oghabian, Mehdi Fazeli, Leyla Pourgholi, Ali Mandegary |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Physiology Iran 010501 environmental sciences Opium Opium Dependence Toxicology medicine.disease_cause 01 natural sciences Lead poisoning Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Genotype NAD(P)H Dehydrogenase (Quinone) medicine Humans 030212 general & internal medicine Aged Glutathione Transferase 0105 earth and related environmental sciences Polymorphism Genetic medicine.diagnostic_test business.industry Opioid use Porphobilinogen Synthase General Medicine Middle Aged medicine.disease Lead Poisoning Oxidative Stress Lead chemistry Toxicity Female Blood lead level business Biomarkers Oxidative stress Food Science medicine.drug |
| Zdroj: | Food and Chemical Toxicology. 120:571-577 |
| ISSN: | 0278-6915 |
| DOI: | 10.1016/j.fct.2018.07.061 |
| Popis: | Use of lead-adulterated opium has become one of the major sources of lead poisoning in Iran. This study was designed to assess clinical effects and oxidative stress and its association with GSTM1, GSTT1, NQO1, and ALAD genes polymorphisms and blood lead level (BLL) in lead-adulterated opium users. The oxidative stress status in 192 opium users with lead poisoning symptoms measured and compared with 102 healthy individuals. Gluthatione S-transferase (GST)-M1 and -T1 genes deletion, NQO1 rs1800566, and δ-aminolevulinic acid dehydratase (ALAD) rs1800435 polymorphisms were determined using PCR and PCR-RFLP. The relation between the polymorphisms, BLL, and oxidative stress parameters were analysed using multivariate linear regressions. The common symptoms of lead toxicity were gastrointestinal and neurologic complications. Oxidative stress was significantly higher in opium addicts and lipid peroxidation significantly correlated with BLL. There was significant association between ALAD rs1800435 and BLL, and the BLL was significantly lower in the patients with ALAD 1-2 genotype. Use of lead-adulterated opium causes high frequency of lead toxicity symptoms, hematological and biochemical abnormalities, and oxidative stress which are associated with BLL. Route of opioid use and the polymorphism of rs1800435 in ALAD gene are the major determinants of BLL in lead-adulterated opium users. |
| Databáze: | OpenAIRE |
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