Prevalence of drug-drug interactions upon addition of simeprevir- or sofosbuvir-containing treatment to medication profiles of patients with HIV and hepatitis C coinfection
| Autor: | Ronish Amin, Arden Koroglu, Mona Nasiri, Liam McGuey, Christopher J. Miller, Louise-Anne McNutt, Nimish Patel, Martha Roman |
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| Rok vydání: | 2014 |
| Předmět: |
Simeprevir
Adult Male medicine.medical_specialty Sofosbuvir Cross-sectional study Immunology HIV Infections Antiviral Agents Risk Factors Virology Internal medicine medicine Prevalence Humans Drug Interactions Sulfonamides business.industry Coinfection Hepatitis C Drug interaction Hepatitis C Chronic Middle Aged medicine.disease Confidence interval Surgery Regimen Infectious Diseases Cross-Sectional Studies Female business Uridine Monophosphate Heterocyclic Compounds 3-Ring medicine.drug |
| Zdroj: | AIDS research and human retroviruses. 31(2) |
| ISSN: | 1931-8405 |
| Popis: | The objectives were to (1) compare the frequency of contraindicated drug-drug interactions (XDDI) when simeprevir (SIM)- and sofosbuvir (SOF)-containing regimens are theoretically added to a patient's medication profile; (2) identify which hepatitis C (HCV) regimen is associated with the lowest frequency of XDDIs within different types of antiretroviral treatment (ART) regimens; and (3) determine the risk factors for XDDIs with each regimen. A cross-sectional study was performed among adult HIV/HCV-coinfected patients. Demographics, comorbidities, and medication lists were collected from medical records. Medication lists were entered into Lexi-Interact drug interaction software and XDDI before/after the addition of SIM- and SOF-containing therapy was documented. Classification and regression tree (CART) analyses identified breakpoints in continuous variables. Before the addition of any HCV therapy, XDDIs were present in 20% of the 335 included patients. After the addition of SIM-containing therapy, the frequency of XDDIs significantly increased to 88.4% (p |
| Databáze: | OpenAIRE |
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