5-Fluorouracil and High-Dose Folinic Acid as Salvage Treatment of Advanced Breast Cancer: An Update
| Autor: | Giovanni Marini, Patrizia Marpicati, A. Zambruni, Alberto Zaniboni, Gorni F, Edda Simoncini |
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| Rok vydání: | 1987 |
| Předmět: |
Cancer Research
medicine.medical_specialty Gastrointestinal Diseases Leucovorin Breast Neoplasms Gastroenterology Folinic acid Breast cancer Internal medicine Antineoplastic Combined Chemotherapy Protocols Mucositis Humans Medicine Bone Marrow Diseases business.industry Remission Induction Cancer Drug Synergism General Medicine medicine.disease Surgery Regimen Oncology Fluorouracil Toxicity Drug Evaluation business Progressive disease medicine.drug |
| Zdroj: | Oncology. 44:336-340 |
| ISSN: | 1423-0232 0030-2414 |
| Popis: | We report an update of our results of a trial of high-dose folinic acid (HDFA) and 5-fluorouracil (5-FU) in advanced breast cancer. Thirty-eight patients with advanced and mainly refractory breast cancer were treated with the following regimen: HDFA (200 mg/m2/day) and 5-FU (340, 370, 400 mg/m2/day) given immediately afterwards, for 5 consecutive days every 4 weeks. Of 36 evaluable patients, 3 achieved complete remission (8%) and 13 partial remission (36%) for an overall response rate of 44%, while 11 patients (30%) had stable disease. Thirteen out of sixteen responders (85%) were pretreated with some 5-FU-containing regimens. The median duration of response was 9.6+ months, the median survival for responders and for patients with stable or progressive disease was 19.9+, 18.8+ and 9 months, respectively. The overall toxicity was acceptable: while hematological toxicity was very mild, oral mucositis, diarrhea and conjunctivitis were major side effects. These results seem very promising and deserve further evaluation. |
| Databáze: | OpenAIRE |
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