PTK-7 Expression in Gastric Cancer: A Prognostic Determinant
| Autor: | Ozlem Ercelep, Abdilkerim Oyman, Mehmet Aliustaoglu, Sevinç Hallaç Keser, Merve Başar, Nagehan Ozdemir Barisik, Selver Işık, Hatice Odabas, Melike Ozcelik, Serhat Özçelik |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine Oncology medicine.medical_specialty Multivariate analysis Gene Expression lcsh:Medicine Disease Cohort Studies 03 medical and health sciences 0302 clinical medicine Stomach Neoplasms Internal medicine Biomarkers Tumor medicine Humans Tyrosine prognostic factor Aged Retrospective Studies Aged 80 and over Regulation of gene expression Chi-Square Distribution business.industry gastric cancer ptk-7 lcsh:R Wnt signaling pathway Receptor Protein-Tyrosine Kinases Cancer Retrospective cohort study General Medicine Middle Aged Prognosis medicine.disease Survival Rate 030104 developmental biology 030220 oncology & carcinogenesis Immunohistochemistry Original Article Female business Cell Adhesion Molecules Follow-Up Studies |
| Zdroj: | Balkan Medical Journal, Vol 37, Iss 2, Pp 91-97 (2020) Balkan Medical Journal |
| ISSN: | 2146-3131 2146-3123 |
| DOI: | 10.4274/balkanmedj.galenos.2019.2019.8.12 |
| Popis: | Background: Protein tyrosine kinase-7, a regulatory protein in the Wnt signaling pathway, was highly overexpressed in various cancer types and assumed to be related to prognosis. Aims: The purpose of this study is to assess whether protein tyrosine kinase-7 expression status in curatively resected gastric carcinoma would independently identify patients with a high risk of recurrence and death. Study Design: Retrospective cohort study. Methods: We included patients who were at least 18 years of age and diagnosed with gastric cancer. The exclusion criterion was a metastatic disease at the time of diagnosis or operation. Data on clinicopathological prognostic determinants and clinical courses, including the date of disease relapse and survival status, were collected with the use of medical records. Surgically removed tumor tissue specimens were examined by two independent pathologists at the pathology department of our institution. Protein tyrosine kinase-7 expression status was assessed with immunohistochemical processing and stratified on a scale ranging from 0 to +3 according to the extent of stained tumor cells. It was then further categorized into two groups, one being + (positive), including +1, +2, and +3 scores, another was-(negative), including-and +/− scores. Results: A total of 114 patients were analyzed. Protein tyrosine kinase-7 expression was present in 66.7% of the surgical tumor specimens. There was no statistically significant difference in almost all relevant parameters between the protein tyrosine kinase-7 positive and negative groups. The estimated median survival in the protein tyrosine kinase-7 positive group was significantly better than the protein tyrosine kinase-7 negative group (60 vs 22 months, p |
| Databáze: | OpenAIRE |
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