Synergistic effect of the association between lidocaine and magnesium sulfate on peri-operative pain after mastectomy: A randomised, double-blind trial
| Autor: | Andrei C. Sposito, Breno Jardim Grossi, Douglas Pellizzaro, Fabricio T Mendonça, Luise Aníbal Calvano, Luiz F. Carvalho |
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| Rok vydání: | 2020 |
| Předmět: |
Lidocaine
Remifentanil Breast Neoplasms 03 medical and health sciences Magnesium Sulfate 0302 clinical medicine Double-Blind Method 030202 anesthesiology medicine Humans General anaesthesia Alfentanil Anesthetics Local Mastectomy Pain Postoperative Morphine business.industry 030208 emergency & critical care medicine Odds ratio Perioperative Confidence interval Analgesics Opioid Regimen Anesthesiology and Pain Medicine Anesthesia business Brazil medicine.drug |
| Zdroj: | European journal of anaesthesiology. 37(3) |
| ISSN: | 1365-2346 |
| Popis: | BACKGROUND Recently, the use of venous adjuvants, such as lidocaine and magnesium sulfate, has been gaining ground in multimodal analgesia. However, no study has evaluated the impact a combination of the two drugs. OBJECTIVES To evaluate the efficacy of venous adjuvants in reducing opioid consumption and pain scores after mastectomy. DESIGN Randomised, double-blind, parallel-group, noninferiority clinical trial with a 1 : 1 : 1 : 1 allocation ratio. SETTING Hospital de Base do Distrito Federal, Brasilia, Federal District, Brazil from November 2014 to December 2017. PATIENTS One-hundred and ninety-eight patients were electively scheduled for mastectomy. Seventy-eight were excluded. INTERVENTIONS Intra-operative infusions of remifentanil (0.1 μg kg min), lidocaine (3 mg kg h), magnesium sulfate (50 mg kg + 15 mg kg h) or lidocaine with magnesium sulfate were used. All patients received standard general anaesthesia. MAIN OUTCOME MEASURES Peri-operative opioid consumption and pain scores. RESULTS The patients who received both lidocaine and magnesium sulfate group (n=30) consumed less alfentanil during surgery (P |
| Databáze: | OpenAIRE |
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