Effect of glutathione onin Vitro metabolism of unsaturated aliphatic nitriles to cyanide
| Autor: | Mohammed Y. H. Farooqui, Enrique Massa |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
Nitrile Health Toxicology and Mutagenesis Cyanide Mitochondria Liver In Vitro Techniques Toxicology chemistry.chemical_compound Cytosol Nitriles Animals Organic chemistry Moiety Glutathione Transferase Cyanides Chemistry Rats Inbred Strains General Medicine Glutathione Metabolism Pollution Rats Toxicity Microsome Methacrylates Aliphatic compound |
| Zdroj: | Bulletin of Environmental Contamination and Toxicology. 46:431-435 |
| ISSN: | 1432-0800 0007-4861 |
| DOI: | 10.1007/bf01688943 |
| Popis: | Aliphatic nitriles are widely used as important solvents and intermediates in polymer, plastic, synthetic fibers, resins, dyestuffs, pharmaceuticals and vitamin industries. Occupational exposure to these chemicals is principally through inhalation and dermal routes. Human and animal toxicity studies have suggested that the toxicity of aliphatic nitriles is due to their cyanide (CN{sup {minus}}) liberating capacity under biological conditions. Despite the common property of CN{sup {minus}} liberation, their are marked differences among nitriles, in the amounts of CN{sup {minus}} released to cause poisoning, in the duration of exposure and toxicity signs. The extent of metabolism of unsaturated aliphatic nitrile is influenced by the structural properties of the molecule. The purpose of this study is to investigate the effects of functional groups, the type of unsaturated moiety and availability of sulfhydryls especially glutathione (GSH) on the in vitro rat liver postmitochondrial fraction (microsomes + cytosol) is used to provide cytosolic GHS transferase, an essential enzyme of GSH metabolism. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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