Increasing Trend in Infection-Related Death-Censored Graft Failure in Renal Transplantation
| Autor: | Alan J. Koffron, Gordan Jacobsen, K. K. Venkat, Marwan S Abouljoud, G. H. Reddy, Ravi Parasuraman |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Graft Rejection Male Urologic Diseases medicine.medical_specialty Graft failure Wilcoxon signed-rank test medicine.medical_treatment Logistic regression Communicable Diseases Postoperative Complications Risk Factors Internal medicine Humans Medicine Kidney transplantation Aged Retrospective Studies Polyomavirus Infections Transplantation business.industry Immunosuppression Odds ratio Middle Aged medicine.disease Kidney Transplantation Confidence interval Surgery Female business |
| Zdroj: | Transplantation. 91:94-99 |
| ISSN: | 0041-1337 |
| Popis: | Background. Advances in kidney transplantation have significantly improved early outcomes but failed to improve long-term graft survival. Despite many causes, the contribution of infection to death-censored graft failure (DCGF) is unknown. The aim of our study is to assess the impact of infections on DCGF using United Network for Organ Sharing data. Methods. We analyzed 38,286 DCGFs among 189,110 first kidney transplants performed between January 1, 1990 and December 31, 2006. Information on infection contributing to DCGF was available in 31,326 DCGF recipients. Student's two-sample t test for normally distributed variables, Wilcoxon rank sum test for nonnormally distributed, and Chi-square test for categorical variables were used in univariable comparisons. Multivariable logistic regression analysis was performed to assess the independent contribution of variables to infection-related DCGF. Results. Overall, infection accounted for 7.7% (2397/31,326) of all DCGF. The rate of infection-related DCGF increased from 6.4% in 1990 to 10.1% in 2006 and was significantly higher during 1997 to 2006 when compared with 1990 to 1996 period (9.1% vs. 6.3%, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|