Reversed theta sequences of hippocampal cell assemblies during backward travel
| Autor: | Karim El Kanbi, Gabrielle Girardeau, Anne Cei, Céline Drieu, Michaël B. Zugaro |
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| Přispěvatelé: | Centre interdisciplinaire de recherche en biologie (CIRB), Labex MemoLife, École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
Quantitative Biology::Tissues and Organs [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology Models Neurological Phase (waves) Precession (mechanical) Action Potentials Hippocampal formation Hippocampus 03 medical and health sciences 0302 clinical medicine Orientation Animals Entorhinal Cortex Rats Long-Evans Treadmill Theta Rhythm ComputingMilieux_MISCELLANEOUS 030304 developmental biology Physics Neurons 0303 health sciences Quantitative Biology::Neurons and Cognition General Neuroscience Track (disk drive) Hippocampal cell Bayes Theorem Electrodes Implanted Rats Space Perception Trajectory human activities Neuroscience 030217 neurology & neurosurgery Locomotion |
| Zdroj: | Nature Neuroscience Nature Neuroscience, Nature Publishing Group, 2014, 17 (5), pp.719-724. ⟨10.1038/nn.3698⟩ |
| ISSN: | 1097-6256 1546-1726 |
| DOI: | 10.1038/nn.3698⟩ |
| Popis: | Hippocampal cell assemblies coding for past, present and future events form theta-timescale (~100 ms) sequences that represent spatio-temporal episodes. However, the underlying mechanisms remain largely unknown. We recorded hippocampal and entorhinal cortical activity as rats experienced backward travel on a model train. Although the firing fields of place cells remained stable, the order in which they were activated in the theta sequence was reversed during backward travel. Thus, hippocampal cell assemblies coordinated their relative timing to correctly predict the sequential traversal of place fields in reverse order. At the single-cell level, theta phase represented distance traveled through the field, even though the head of the rat was oriented opposite to travel direction and entorhinal head-direction cells maintained their preferred firing direction. Our results challenge most theoretical models of theta sequence generation in the hippocampus. |
| Databáze: | OpenAIRE |
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