Polysaccharide-protein complex-decorated selenium nanosystem as an efficient bone-formation therapeutic
| Autor: | Tianfeng Chen, Siu To Cheung, Keith Kwong Hon Wong, Siming Yu, Kevin W.H. Kwok, Kar Him Luk |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
Chemistry Osteoporosis Biomedical Engineering chemistry.chemical_element Osteoblast 02 engineering and technology General Chemistry General Medicine 010402 general chemistry 021001 nanoscience & nanotechnology Polysaccharide medicine.disease 01 natural sciences In vitro 0104 chemical sciences Cell biology medicine.anatomical_structure In vivo medicine General Materials Science Bone formation 0210 nano-technology Signalling pathways Selenium |
| Zdroj: | Journal of materials chemistry. B. 6(32) |
| ISSN: | 2050-7518 |
| Popis: | Polysaccharide-protein complex-coated selenium nanoparticles (PTR-SeNPs) system has been rationally designed and identified as a potent bone-formation therapeutic to antagonize osteoporosis. The nanosystem presents high cellular uptake in osteoblast cells and significantly enhances bone formation in vitro and in vivo, mainly through BMP-2/Smad-mediated signalling pathways. |
| Databáze: | OpenAIRE |
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